Evidence map›Paper›PMID 33099743›Full record

ArticleMolecular neurobiology2021

Protective Role of Low Ethanol Administration Following Ischemic Stroke via Recovery of KCC2 and p75

Stanislav Khirug, Shetal Soni, Marta Saez Garcia, Marine Tessier, Liang Zhou, Natalia Kulesskaya, Heikki Rauvala, Dan Lindholm, Anastasia Ludwig, Florence Molinari and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Stanislav Khirug *Neuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland. stanislav.khirug@helsinki.fi.
Shetal Soni *Neuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland.
Marta Saez GarciaNeuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland.
Marine TessierINMED (INSERM U1249), Aix-Marseille Université, Marseille, France.
Liang ZhouNeuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland.
Natalia KulesskayaNeuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland.
Heikki RauvalaNeuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland.
Dan LindholmMedicum, Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Anastasia LudwigNeuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland.
Florence MolinariINMED (INSERM U1249), Aix-Marseille Université, Marseille, France.
Claudio RiveraNeuroscience Center-HiLIFE, University of Helsinki, 00014, Helsinki, Finland. claudio.rivera@helsinki.fi.ORCID http://orcid.org/0000-0003-2462-6561
University of Helsinki · FIInserm · FR

Funding

Academy of Finland 259799 and 308265Academy of Finland SA250742Agence Nationale de la Recherche NR-Traumep-13-BSV4-0012-01Fondation des Gueules Casées N° 83-2020
6 · The paper itself

Abstract

A striking result from epidemiological studies show a correlation between low alcohol intake and lower incidence for ischemic stroke and severity of derived brain injury. Although reduced apoptosis and inflammation has been suggested to be involved, little is known about the mechanism mediating this effect in vivo. Increase in intracellular chloride concentration and derived depolarizing GABA

Indexed as

AnimalsApoptosisBiological TransportBiomarkersBrain InfarctionCell SurvivalChloridesDietElectrophysiological PhenomenaEthanolgamma-Aminobutyric AcidInflammationIschemic StrokeK Cl- CotransportersMaleMiceBiomarkersChloridesEthanolgamma-Aminobutyric AcidK Cl- CotransportersNeuroprotective AgentsReceptors, Nerve Growth FactorSymportersApoptosisChloride homeostasisGABAA transmissionNeurotrophinesTrauma

Identifiers

PMID33099743
PMCPMC7878264
OpenAlexW3094029610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.