ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2021
Dengue and post-infection fatigue: findings from a prospective cohort-the Colombo Dengue Study.
Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Dengue virus infection.Nature reviews. Disease primers · 2026Review
- Review
- Clinical Characteristics of Hospitalized Patients with Dengue Fever in Guangzhou, China.Infection and drug resistance · 2026Article
- Integrating the Wei-Qi-Ying-Blood Theory with Modern Pathophysiology: A Multitarget Translational Framework for Dengue Management.International journal of general medicine · 2026Review
- Review
- Residual Symptoms and Quality of Life After Treated Lyme Neuroborreliosis: Case-Control Study (QoLYME).Open forum infectious diseases · 2025Article
- Global prevalence and risk factors of fatigue and post-infectious fatigue among patients with dengue: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Article
- Pathophysiology and clinical implications of dengue-associated neurological disorders.Frontiers in microbiology · 2025Review
- Dengue Fever—Diagnosis, Risk Stratification, and Treatment.Deutsches Arzteblatt international · 2024Review
- Primary Dengue and Long-Term Health Status in Madeira Island, Portugal: A Retrospective Questionnaire-Based Study.The American journal of tropical medicine and hygiene · 2024Article
- Dengue.Lancet (London, England) · 2024Review
- A prospective cohort study on post COVID syndrome from a tertiary care centre in Sri Lanka.Scientific reports · 2023Article
- Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination.European archives of psychiatry and clinical neuroscience · 2023Article
- Article
- Development of a machine learning model for early prediction of plasma leakage in suspected dengue patients.PLoS neglected tropical diseases · 2023Article
- Persistent morbidity in Clade IIb mpox patients: interim results of a long-term follow-up study, Belgium, June to November 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- Post-Viral Fatigue Following SARS-CoV-2 Infection during Pregnancy: A Longitudinal Comparative Study.International journal of environmental research and public health · 2022Article
- Effect of prior Zika and dengue virus exposure on the severity of a subsequent dengue infection in adults.Scientific reports · 2022Article
- Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness.PLoS neglected tropical diseases · 2022Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundPrevious studies on post-infection fatigue in dengue are few but suggest that up to 25% of dengue patients may suffer from fatigue. This study aimed to evaluate the prevalence and associations of post-infection fatigue in dengue patients compared with non-dengue fever patients.
methodsPost-infection fatigue and its demographic and clinical associations were assessed in adult dengue and non-dengue fever patients 2 months after the acute infection in a prospective cohort study in Sri Lanka. Fatigue at 2 months (primary endpoint) was assessed with the fatigue questionnaire as a dichotomous outcome based on a pre-recommended cut-off (score ≥4) and as the total score from the questionnaire (higher score indicates more fatigue).
resultsOf 260 patients, 158 had dengue and, of these, 51 (32%) had fatigue at 2 months. Risk was higher in dengue patients (vs non-dengue; relative risk [RR] 4.93 [95% confidence interval {CI} 2.3 to 10.4]) and more so in female dengue patients (vs male dengue patients; RR 2.45 [95% CI 1.24 to 4.86]). Severe dengue patients had a higher mean fatigue score (p=0.024).
conclusionsPost-infection fatigue is an underappreciated burden of this widely prevalent infection. Our findings are useful to triage patients at risk of fatigue for follow-up.
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