Evidence map›Paper›PMID 33099475›Full record

ArticleCancer genomics & proteomics

The Association Between the Genetic

Desta A Beyene, Mohammad R Daremipouran, Victor Apprey, Tammey Naab, Olakunle O Kassim, Robert L Copeland, Yasmine M Kanaan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Desta A BeyeneCancer Center, Howard University, Washington, DC, U.S.A.
Mohammad R DaremipouranCancer Center, Howard University, Washington, DC, U.S.A.
Victor AppreyCommunity and Family Medicine, College of Medicine, Howard University, Washington, DC, U.S.A.
Tammey NaabDepartment of Pathology, College of Medicine, Howard University, Washington, DC, U.S.A.
Olakunle O KassimDepartment of Microbiology, College of Medicine, Howard University, Washington, DC, U.S.A.
Robert L CopelandDepartment of Pharmacology, College of Medicine, Howard University, Washington, DC, U.S.A. ymkanaan@howard.edu rlcopeland@howard.edu.
Yasmine M KanaanCancer Center, Howard University, Washington, DC, U.S.A. ymkanaan@howard.edu rlcopeland@howard.edu.
Howard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer (PCa) is a multifactorial disease involving complex interactions between genetic and physiological/environmental factors. Vitamin D receptor (VDR) plays a role in numerous cellular pathways and it has been suggested that VDR genetic variants influence individual susceptibility to PCa. MATERIALS AND

methodsLogistic regression analysis was used to assess the association of six VDR single nucleotide polymorphisms (SNPs) and factors such as tanning potential and UV sunlight exposure with PCa risk.

resultsMarginal significant interactions were found, with a 2-fold increase risk of PCa between SNP 1 (c.278-69G>A) and sunlight UV exposure [odds ratio (OR)=2.02, 95% confidence intervaI (CI)=1.036-4.36; p=0.05]; and a 4-fold increase risk of PCa between SNP 4 (c.907+75C>T) and tanning potential (OR=4.40, 95% CI=0.89-29.12; p=0.0591). In contrast, SNP 5 (rs731236, TaqI) and tanning potential interaction had a protective effect by reducing the risk of PCa by 55% (β=-0.804; OR=0.448, 95% CI=0.197-9.42; p=0.0427). SNPs 2 (rs61614328) and 6 (rs533037428) did not show any association with PCa even in the presence of UV sunlight exposure.

conclusionThe protective effect of SNP 4 from PCa is lost and modified by tanning potential in African Americans. This finding needs to be verified by larger studies in different ethnic populations.

Indexed as

Polymorphism, Single NucleotideAdultAgedCase-Control StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedPrognosisProstatic NeoplasmsReceptors, CalcitriolRisk FactorsSunbathingUltraviolet RaysReceptors, CalcitriolVDR protein, humanAfrican American menProstate cancersingle nucleotide polymorphismvitamin Dvitamin D receptor gene

Identifiers

PMID33099475
PMCPMC7675656
OpenAlexW3093607571

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.