ReviewThe journal of investigative dermatology. Symposium proceedings2020
Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model.
Review in The journal of investigative dermatology. Symposium proceedings, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Changes in T-cell subsets and their association with disease severity in patients with alopecia areata.Turkish journal of medical sciences · 2026Article
- Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant.Frontiers in immunology · 2024Article
- Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.PNAS nexus · 2023Article
- The Emergent Power of Human Cellular vs Mouse Models in Translational Hair Research.Stem cells translational medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 4 countries.
Funding
Abstract
The C3H/HeJ model has long dominated basic alopecia areata (AA) in vivo research and has been used as proof-of-principle that Jak inhibitors are suitable agents for AA management in vivo. However, its histologic features are not typical of human AA, and it is questionable whether it is sufficiently clinically predictive for evaluating the therapeutic effects of candidate AA agents. Instead, the humanized mouse model of AA has been used to functionally demonstrate the role of key immune cells in AA pathogenesis and to discover human-specific pharmacologic targets in AA management. Therefore, we advocate the use of both models in future preclinical AA research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.