ArticleEBioMedicine2020
The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study.
Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 31 citations in OpenAlex.
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults.GeroScience · 2026Article
- Neural oscillations serving abstract reasoning are differentially associated with inflammatory markers in people with HIV.Brain, behavior, and immunity · 2026Article
- Elevated neurotransmitter levels in people with HIV are associated with attention function.Neurobiology of disease · 2026Article
- Elevated inflammation in people with HIV is associated with aberrant neural oscillations serving selective attention.Journal of neuroinflammation · 2026Article
- Oscillatory Dynamics Serving Verbal Working Memory Differ in People with HIV and Are Linked To Disease Duration.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Cannabis- and HIV-related perturbations to the cortical gamma dynamics supporting inhibitory processing.Brain communications · 2025Article
- High-definition transcranial direct current stimulation of the right inferior parietal modulates oscillatory activity in higher-order regions serving attention reorientation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- zBMI scales with multispectral alterations in the neural oscillatory dynamics serving verbal working memory in youth.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional alteration of divided attention in people living with HIV based on a task-fMRI study.Frontiers in neuroscience · 2025Article
- People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility.Neurobiology of disease · 2024Article
- Optimal gamma-band entrainment of visual cortex.Human brain mapping · 2024Article
- Neuromodulatory effects of parietal high-definition transcranial direct-current stimulation on network-level activity serving fluid intelligence.The Journal of physiology · 2024Article
- Neurotoxic effects of home radon exposure on oscillatory dynamics serving attentional orienting in children and adolescents.NeuroImage · 2024Article
- Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension.The Journal of physiology · 2024Article
- Spontaneous cortical activity is altered in persons with HIV and related to domain-specific cognitive function.Brain communications · 2024Article
- Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder.Neurobiology of disease · 2023Article
- Resting state network connectivity alterations in HIV: Parallels with aging.Human brain mapping · 2023Article
- Imaging of Brain Structural and Functional Effects in People With Human Immunodeficiency Virus.The Journal of infectious diseases · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDespite living a normal lifespan, at least 35% of persons with HIV (PWH) in resource-rich countries develop HIV-associated neurocognitive disorder (HAND). This high prevalence of cognitive decline may reflect accelerated ageing in PWH, but the evidence supporting an altered ageing phenotype in PWH has been mixed.
methodsWe examined the impact of ageing on the orienting of visual attention in PWH using dynamic functional mapping with magnetoencephalography (MEG) in 173 participants age 22-72 years-old (94 uninfected controls, 51 cognitively-unimpaired PWH, and 28 with HAND). All MEG data were imaged using a state-of-the-art beamforming approach and neural oscillatory responses during attentional orienting were examined for ageing, HIV, and cognitive status effects.
findingsAll participants responded slower during trials that required attentional reorienting. Our functional mapping results revealed HIV-by-age interactions in left prefrontal theta activity, alpha oscillations in the left parietal, right cuneus, and right frontal eye-fields, and left dorsolateral prefrontal beta activity (p<.005). Critically, within PWH, we observed a cognitive status-by-age interaction, which revealed that ageing impacted the oscillatory gamma activity serving attentional reorienting differently in cognitively-normal PWH relative to those with HAND in the left temporoparietal, inferior frontal gyrus, and right prefrontal cortices (p<.005).
interpretationThis study provides key evidence supporting altered ageing trajectories across vital attention circuitry in PWH, and further suggests that those with HAND exhibit unique age-related changes in the oscillatory dynamics serving attention function. Additionally, our neural findings suggest that age-related changes in PWH may serve a compensatory function.
fundingNational Institutes of Health, USA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.