ReviewCortex; a journal devoted to the study of the nervous system and behavior2020
Gesture deficits and apraxia in schizophrenia.
Review in Cortex; a journal devoted to the study of the nervous system and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06949449 (Upper Limb Functional Capacity in Individuals Diagnosed With Mental Disorders), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Upper Limb Functional Capacity in Individuals Diagnosed With Mental Disorders: A Cross-Sectional Study
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The Neurocognitive Bases of Meaningful Intransitive Gestures: A Systematic Review and Meta-analysis of Neuropsychological Studies.Neuropsychology review · 2025Pooled it
- Gesture deficits in psychosis and the combination of group psychotherapy and transcranial magnetic stimulation: A randomized clinical trial.Molecular psychiatry · 2025Trial
- Aberrant gesture use in autism spectrum disorders is unrelated to motor abnormalities.European archives of psychiatry and clinical neuroscience · 2026Article
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- Gesture Impairments in Schizophrenia: Distinct Roles of Negative Symptoms and Formal Thought Disorder.Schizophrenia bulletin · 2026Article
- Transdiagnostic associations between subjective gesture behaviour and objective performance in schizophrenia and depression.Translational psychiatry · 2026Article
- Language, Motor Ability and Related Deficits in Children at Familial Risk of Schizophrenia or Bipolar Disorder.Schizophrenia bulletin · 2025Article
- A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms.Schizophrenia bulletin · 2025Article
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
- Apraxia: From Neuroanatomical Pathways to Clinical Manifestations.Current neurology and neuroscience reports · 2024Review
- Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood.Psychological medicine · 2023Article
- Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2023Article
- Electroencephalographic Effective Connectivity Analysis of the Neural Networks during Gesture and Speech Production Planning in Young Adults.Brain sciences · 2023Article
- Using virtual reality to assess gesture performance deficits in schizophrenia patients.Frontiers in psychiatry · 2023Article
- Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence.Schizophrenia (Heidelberg, Germany) · 2022Review
- Motion energy analysis during speech tasks in medication-naïve individuals with at-risk mental states for psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Neural Correlates of Variation in Personal Space and Social Functioning in Schizophrenia and Healthy Individuals.Schizophrenia bulletin · 2022Article
- Motor Behavior is Relevant for Understanding Mechanism, Bolstering Prediction, And Improving Treatment: A Transdiagnostic Perspective.Schizophrenia bulletin · 2022Article
- Using dynamic point light display stimuli to assess gesture deficits in schizophrenia.Schizophrenia research. Cognition · 2022Article
- Validation of the Apraxia Screen TULIA (AST) in Schizophrenia.Neuropsychobiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Aberrant performance of skilled action has long been noted in schizophrenia and relatedly, recent reports have demonstrated impaired use, performance, and perception of hand gestures in this group. Still, this deficit is not acknowledged as apraxia, which to the broader medical field, characterizes impairments in skilled actions. Understanding the relationship between apraxia and schizophrenia may shed an invaluable new perspective on disease mechanism, and highlight novel treatment opportunities as well. To examine this potential link, we reviewed the evidence for the types of praxis errors, associated psychopathology, and cerebral correlates of the praxis deficit in schizophrenia. Notably, the review indicated that gesture deficits are severe enough to be considered genuine apraxia in a substantial proportion of patients (about 25%). Further, other potential contributors (e.g., hypokinetic motor abnormalities, cognitive impairment) are indeed associated with gesture deficits in schizophrenia, but do not sufficiently explain the abnormality. Finally, patients with praxis deficits have altered brain structure and function including the left parieto-premotor praxis network and these neural correlates are specific to the praxis deficit. Therefore, we argue that the gestural disorder frequently observed in schizophrenia shares both the clinical and neurophysiological features of true apraxia, as in other neuropsychiatric disorders with impaired higher order motor control, such as Parkinson's disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.