Evidence map›Paper›PMID 33099009›Full record

ArticleNeuroImage2021

Characterising group-level brain connectivity: A framework using Bayesian exponential random graph models.

B C L Lehmann, R N Henson, L Geerligs, Cam-Can, S R White

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Statistical Brain Network Analysis.Annual review of statistics and its application · 2024
    Article
  6. Secondary analysis: Graph analysis of brain connectivity network in autism spectrum disorder.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. A regression framework for brain network distance metrics.Network neuroscience (Cambridge, Mass.) · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

B C L LehmannMRC Biostatistics Unit, University of Cambridge, UK; Big Data Institute, University of Oxford, UK; Department of Statistics, University of Oxford, UK. Electronic address: brieuc.lehmann@bdi.ox.ac.uk.
R N HensonMRC Cognition and Brain Sciences Unit, University of Cambridge, UK.
L GeerligsDonders Institute for Brain, Cognition and Behaviour, Radboud University, UK.
Cam-CanCambridge Centre for Ageing and Neuroscience (Cam-CAN), University of Cambridge and MRC Cognition and Brain Sciences Unit, Cambridge, UK.
S R WhiteMRC Biostatistics Unit, University of Cambridge, UK; Department of Psychiatry, University of Cambridge, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/H008217/1Department of HealthMedical Research Council MC_UU_00005/8Medical Research Council SUAG/046 G101400Medical Research Council U105292687
6 · The paper itself

Abstract

The brain can be modelled as a network with nodes and edges derived from a range of imaging modalities: the nodes correspond to spatially distinct regions and the edges to the interactions between them. Whole-brain connectivity studies typically seek to determine how network properties change with a given categorical phenotype such as age-group, disease condition or mental state. To do so reliably, it is necessary to determine the features of the connectivity structure that are common across a group of brain scans. Given the complex interdependencies inherent in network data, this is not a straightforward task. Some studies construct a group-representative network (GRN), ignoring individual differences, while other studies analyse networks for each individual independently, ignoring information that is shared across individuals. We propose a Bayesian framework based on exponential random graph models (ERGM) extended to multiple networks to characterise the distribution of an entire population of networks. Using resting-state fMRI data from the Cam-CAN project, a study on healthy ageing, we demonstrate how our method can be used to characterise and compare the brain's functional connectivity structure across a group of young individuals and a group of old individuals.

Indexed as

Bayes TheoremModels, NeurologicalBrainBrain MappingHumansIndividualityMagnetic Resonance ImagingModels, StatisticalNerve NetNeural PathwaysBayesian ERGMExponential Random Graph Model (ERGM)FmriGroup studiesNetwork neuroscience

Identifiers

PMID33099009
PMCPMC7613122

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.