ReviewEnvironmental research2021
Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO.
Review in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Quantifying the association between PMEnvironmental health : a global access science source · 2024Pooled it
- Prenatal exposure to air pollution and maternal and fetal thyroid function: a systematic review of the epidemiological evidence.Environmental health : a global access science source · 2024Pooled it
- Prenatal Exposure to Air Pollutants and Attentional Deficit Hyperactivity Disorder Development in Children: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- A systematic review of evidence for maternal preconception exposure to outdoor air pollution on Children's health.Environmental pollution (Barking, Essex : 1987) · 2023Pooled it
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Within- and between-study site variations in ambient air pollution exposure at ages 9-10 years in the Adolescent Brain Cognitive Development (ABCD) Study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Prenatal Exposure to Nitrogen Dioxide, Fine Particulates, and Ozone in Relation to Child Behavior: The Environmental Influences on Child Health Outcomes Cohort.Environmental science & technology · 2026Article
- Ambient air pollution during pregnancy and offspring cerebral palsy.Environment international · 2026Article
- Association between early life constituent-specific PMBMC medicine · 2026Article
- Pre- and postnatal exposure to PMEnvironmental research · 2026Article
- Associations of prenatal fine particulate matter mixtures with neurodevelopmental outcomes in early childhood: component- and source-specific insights.Particle and fibre toxicology · 2026Article
- Particulate Air Pollution, Disease, and Death in the Cities and Towns of Southwestern Pennsylvania.Annals of global health · 2026Article
- Children's environmental health, environmental justice and PM2.5 regulation in the US, 1997-2024.Environmental health : a global access science source · 2025Article
- Exposure to violence and socioeconomic deprivation in susceptibility to nitrogen dioxide on term infant birthweight in New York City.Environmental health : a global access science source · 2025Article
- Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children's learning difficulties.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Air Pollution Exposure, Prefrontal Connectivity, and Emotional Behavior in Early Adolescence.Research report (Health Effects Institute) · 2025Article
- The next 1000 days: building on early investments for the health and development of young children.Lancet (London, England) · 2024Review
- Prenatal PMEnvironment & health (Washington, D.C.) · 2024Article
- Short term air pollution exposure during pregnancy and associations with maternal immune markers.Environmental research · 2024Article
- Assessing prenatal and early childhood social and environmental determinants of health in the HEALthy Brain and Child Development Study (HBCD).Developmental cognitive neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundAir pollution exposure is ubiquitous with demonstrated effects on morbidity and mortality. A growing literature suggests that prenatal air pollution exposure impacts neurodevelopment. We posit that the Environmental influences on Child Health Outcomes (ECHO) program will provide unique opportunities to fill critical knowledge gaps given the wide spatial and temporal variability of ECHO participants.
objectivesWe briefly describe current methods for air pollution exposure assessment, summarize existing studies of air pollution and neurodevelopment, and synthesize this information as a basis for recommendations, or a blueprint, for evaluating air pollution effects on neurodevelopmental outcomes in ECHO.
methodsWe review peer-reviewed literature on prenatal air pollution exposure and neurodevelopmental outcomes, including autism spectrum disorder, attention deficit hyperactivity disorder, intelligence, general cognition, mood, and imaging measures. ECHO meta-data were compiled and evaluated to assess frequency of neurodevelopmental assessments and prenatal and infancy residential address locations. Cohort recruitment locations and enrollment years were summarized to examine potential spatial and temporal variation present in ECHO. DISCUSSION: While the literature provides compelling evidence that prenatal air pollution affects neurodevelopment, limitations in spatial and temporal exposure variation exist for current published studies. As >90% of the ECHO cohorts have collected a prenatal or infancy address, application of advanced geographic information systems-based models for common air pollutant exposures may be ideal to address limitations of published research.
conclusionsIn ECHO we have the opportunity to pioneer unifying exposure assessment and evaluate effects across multiple periods of development and neurodevelopmental outcomes, setting the standard for evaluation of prenatal air pollution exposures with the goal of improving children's health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.