ArticleImmunity2020
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.
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Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- A dynamic RNA hub facilitates activation-induced cytidine deaminase recruitment to the immunoglobulin heavy-chain locus.Molecular cell · 2026Article
- CTCF directly binds G-quadruplex structures to regulate genome topology and gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- DNA secondary structures in BCL2 and MYC elicit activation-induced cytidine deaminase binding and activity.Nucleic acids research · 2026Article
- G-quadruplex structures are key regulators of mammalian spermatogenesis.Cellular & molecular biology letters · 2026Article
- Increased IGF-1 and DNA Synthesis in Patients With Activation-Induced Cytidine Deaminase Deficiency.Journal of immunology research · 2026Article
- B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2024Article
- Alternative DNA structures in hematopoiesis and adaptive immunity.Advances in immunology · 2024Review
- Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency.Frontiers in immunology · 2024Article
- Detection of alternative DNA structures and its implications for human disease.Molecular cell · 2023Review
- Distinct metabolic requirements regulate B cell activation and germinal center responses.Nature immunology · 2023Article
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis.RSC chemical biology · 2023Article
- Roles of G4-DNA and G4-RNA in Class Switch Recombination and Additional Regulations in B-Lymphocytes.Molecules (Basel, Switzerland) · 2023Review
- AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination.Science advances · 2022Article
- Triple-helix potential of the mouse genome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The role of B cells in the development, progression, and treatment of lymphomas and solid tumors.Advances in immunology · 2022Review
- TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures.Nature immunology · 2022Article
- The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Relevance of G-Quadruplexes for DNA Repair.International journal of molecular sciences · 2021Review
- A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
William T YewdellImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Youngjun KimImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Priyanka ChowdhuryImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Colleen M LauImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ryan M SmolkinGerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA.
Kalina T BelchevaBiochemistry, Cellular and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Keith C FernandezImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Montserrat ColsImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Wei-Feng YenImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Bharat VaidyanathanImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Davide AngelettiLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Adrian B McDermottVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Jonathan W YewdellLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Joseph C SunImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA.
Jayanta ChaudhuriImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA. Electronic address: chaudhuj@mskcc.org.
Memorial Sloan Kettering Cancer Center · USCornell University · USNational Institutes of Health · USKettering University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTraining and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Bao Q Vuong · 2008 to 2026
$28.9MTraining and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADRIANA ESPINOSA, FRANCESCA M GANY · 2008 to 2026
$28.1MThe natural killer cell response against mouse cytomegalovirus infectionR01AI100874 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Joseph Chai-Yuen Sun · 2012 to 2026
$7.4MMechanistic Elucidation of Class Switch Recombination and Somatic HypermutationR01AI072194 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CHAUDHURI, JAYANTA · 2009 to 2025
$6.9MRNA-directed targeting of AID in immunity and genomic integrityR01AI124186 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Jayanta Chaudhuri · 2016 to 2026
$4.8MIMMUNOLOGY RESEARCH TRAININGT32CA009149 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI RUDENSKY, ALEXANDER Y · 1985 to 2022
$4.0MRegulation of Nfil3 in innate lymphocyte-mediated host immunityR01AI130043 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI SUN, JOSEPH CHAI-YUEN · 2017 to 2021
$2.8MMechanistic Elucidation of Class Switch Recombination and Somatic HypermutationR56AI072194 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CHAUDHURI, JAYANTA · 2020 to 2020
$531kNCI NIH HHS P30 CA008748NCI NIH HHS T32 CA009149NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NIAID NIH HHS R01 AI072194NIAID NIH HHS R01 AI100874NIAID NIH HHS R01 AI124186NIAID NIH HHS R01 AI130043NIAID NIH HHS R56 AI072194
Abstract
Precise targeting of activation-induced cytidine deaminase (AID) to immunoglobulin (Ig) loci promotes antibody class switch recombination (CSR) and somatic hypermutation (SHM), whereas AID targeting of non-Ig loci can generate oncogenic DNA lesions. Here, we examined the contribution of G-quadruplex (G4) nucleic acid structures to AID targeting in vivo. Mice bearing a mutation in Aicda (AID
Indexed as
G-QuadruplexesMutationAnimalsB-LymphocytesChromatinComputational BiologyCytidine DeaminaseDisease Models, AnimalDisease SusceptibilityEnzyme ActivationFluorescent Antibody TechniqueGene Expression ProfilingGenome-Wide Association StudyGerminal CenterHLA AntigensHumansChromatinCytidine DeaminaseHLA Antigensactivation-induced cytidine deaminaseAIDclass switch recombinationCSRdiffuse large B cell lymphomaDLBCLG4germinal center B cellsG-quadruplexHIGMhyper-IgM syndromeMHC class IIMHCIISHMsomatic hypermutation
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