ArticleImmunity2020
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.
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Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 1 of them a synthesis that pooled it.
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182citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
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Who cites it
182 citing papers in PubMed, 1 synthesis or guideline pooled it, 274 citations in OpenAlex.
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- Tac1 deficiency reduces the severity of enteric bacterial infection.PLoS pathogens · 2026Article
- The genesis of cutaneous neurogenic inflammation is a multi-step process requiring dendritic cell aggregation.Immunity · 2026Article
- Review
- Pirt promotes substance P release in cancer-induced bone pain.Pain reports · 2026Article
- Beyond IgE blocking: Reframing allergen immunotherapy through innate immune regulation.The World Allergy Organization journal · 2026Article
- Epithelial-immune interface in asthma: Mechanistic insights driving novel therapeutic strategies.Seminars in immunopathology · 2026Review
- The SP-MrgprX2 Axis in Allergic Rhinitis: a Neuro-immune Paradigm Beyond IgE-mediated Inflammation.Clinical reviews in allergy & immunology · 2026Review
- Sex- and Gender-Related Differences in Pruritus in Dermatological Diseases: Insights into Inflammatory, Autoimmune, and Connective Tissue Disorders.Life (Basel, Switzerland) · 2026Review
- Wired for immunity: neuroimmune control of the lung by sensory neurons.Nature reviews. Neuroscience · 2026Review
- Neuromodulation strategies in postburn care for pain rehabilitation and scar remodelling.Communications medicine · 2026Review
- VipCell reports · 2026Article
- γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy.Clinical reviews in allergy & immunology · 2026Review
- Environmental factors that regulate host-helminth interactions.Trends in parasitology · 2026Review
- The Neuroimmune Connectome: Understanding how the Peripheral Nervous System shapes Immunity.ImmunoHorizons · 2026Review
- Nociceptor neurons shape antiviral immunity.Journal of neuroinflammation · 2026Review
- Article
- Anterior Cervical Discectomy and Fusion Modulates Inflammatory Factors and Pain Mediators in Cervical Disc Herniation With Neurogenic Pain.Orthopaedic surgery · 2026Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Caroline PernerCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Cameron H FlayerCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Xueping ZhuCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Pamela A AderholdCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Zaynah N A DewanCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Tiphaine VoisinDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Ryan B CamireCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Ohn A ChowCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Isaac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Caroline L SokolCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: clsokol@mgh.harvard.edu.
Harvard University · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1991 to 2026
$35.3MResearch Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6MPain and Neuro-immune Signaling in S. pyogenes pathogenesisR01AI130019 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG, WESSELS, MICHAEL R · 2017 to 2021
$3.2MSensory Neuron-Bacteria Interactions in Modulating Pain and the Host MicrobiotaDP2AT009499 · NCCIH · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2016 to 2019
$2.7MThe Role of Innate Immune Cell Trafficking in Th2 DifferentiationK08AI121421 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SOKOL, CAROLINE LAUREN · 2016 to 2020
$990kInflux Flow CytometerS10OD016372 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI PREFFER, FREDERIC IRA · 2013 to 2013
$600kImageStream X Analyzer 2011S10OD012027 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI PREFFER, FREDERIC IRA · 2012 to 2012
$595kTranslational Immunology Core's FACSAria Cell SorterS10RR023440 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI PREFFER, FREDERIC IRA · 2008 to 2008
$500kDEPARTMENT OF PATHOLOGY LSR2 CYTOMETER: TRANSPLANTATIONS10RR020936 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI PREFFER, FREDERIC IRA · 2005 to 2005
$389kNCCIH NIH HHS DP2 AT009499NCRR NIH HHS S10 RR020936NCRR NIH HHS S10 RR023440NHLBI NIH HHS T32 HL116275NIAID NIH HHS K08 AI121421NIAID NIH HHS R01 AI130019NIDDK NIH HHS P30 DK043351NIH HHS S10 OD012027NIH HHS S10 OD016372
Abstract
Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are marked by their expression of CD301b. CD301b
Indexed as
AllergensAnimalsBiomarkersCell MovementDendritic CellsFemaleGanglia, SpinalHypersensitivityMaleMiceSensory Receptor CellsSubstance PAllergensBiomarkersSubstance Pallergychemotaxisdendritic cellsMRGPRA1sensory neuronsSubstance PTh2TRPV1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.