Evidence map›Paper›PMID 33098753›Full record

ArticlePediatric blood & cancer2020

Are children with SARS-CoV-2 infection at high risk for thrombosis? Viscoelastic testing and coagulation profiles in a case series of pediatric patients.

Maha Al-Ghafry, Banu Aygun, Abena Appiah-Kubi, Adrianna Vlachos, Gholamabbas Ostovar, Christine Capone, Tod Sweberg, Nancy Palumbo, Pratichi Goenka, Lawrence W Wolfe and 2 more

Open access · greenAbstract readComment
In one paragraph

Article in Pediatric blood & cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  8. Thromboprophylaxis for children hospitalized with COVID-19 and MIS-C.Research and practice in thrombosis and haemostasis · 2022
    Article
  9. Article
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  12. Article
  13. Article
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  16. Observational
  17. The Trilogy of SARS-CoV-2 in Pediatrics (Part 3): Thrombosis, Anticoagulant, and Antiplatelet Considerations.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021
    Review
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Maha Al-GhafryDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, New Hyde Park, New York.ORCID 0000-0003-0581-0291
Banu AygunDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, New Hyde Park, New York.ORCID 0000-0001-9934-5161
Abena Appiah-KubiDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, New Hyde Park, New York.
Adrianna VlachosDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, New Hyde Park, New York.ORCID 0000-0003-4068-5406
Gholamabbas OstovarDivision of Pediatric Infectious Disease, Cohen Children's Medical Center, New Hyde Park, New York.
Christine CaponeDivision of Pediatric Critical Care Medicine, Cohen Children's Medical Center, New Hyde Park, New York.
Tod SwebergDivision of Pediatric Critical Care Medicine, Cohen Children's Medical Center, New Hyde Park, New York.
Nancy PalumboDivision of Pediatrics, Cohen Children's Medical Center, New Hyde Park, New York.
Pratichi GoenkaDivision of Pediatrics, Cohen Children's Medical Center, New Hyde Park, New York.
Lawrence W WolfeDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, New Hyde Park, New York.
Jeffrey M LiptonDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, New Hyde Park, New York.
Suchitra S AcharyaDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Cohen Children's Medical Center, New Hyde Park, New York.
Cohen Children's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coagulopathy of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well documented in adults, with increases in D-dimer and prothrombin time found to be strong predictors of mortality, and anticoagulation shown to decrease this mortality. Viscoelastic parameters such as elevations in maximum clot firmness (MCF) on rotational thromboelastometry (ROTEM) have correlated with a hypercoagulable state in adults with SARS-CoV-2. We report our experience in children infected with SARS-CoV-2, with noted elevations in D-dimer and MCF on ROTEM (indicating hypercoagulability). Exploration of viscoelastic testing to provide additional laboratory-based evidence for pediatric-specific risk assessment for thromboprophylaxis in SARS-CoV-2 is warranted.

Indexed as

Coronavirus InfectionsPandemicsPneumonia, ViralSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusThrombosisVenous ThromboembolismAdultAnticoagulantsBetacoronavirusChildCOVID-19HumansSARS-CoV-2AnticoagulantscoagulationCOVID-19rotational thromboelastometryROTEMSARS-CoV-2thrombosisviscoelastic testing

Identifiers

PMID33098753
PMCPMC7645957
OpenAlexW3093971672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.