ArticleMovement disorders : official journal of the Movement Disorder Society2021
The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Pramipexole modulates fronto-subthalamic pathway in sequential working memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Subthalamic stimulation modulates working memory-related cortical dynamics in Parkinson's disease.Brain communications · 2026Article
- Localization and connections of the tail of caudate and caudal putamen in mouse brain.Frontiers in neural circuits · 2025Article
- Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease.Brain and behavior · 2024Article
- Methamphetamine abuse impairs sequential working memory.Frontiers in psychiatry · 2024Article
- Altered alpha and theta oscillations correlate with sequential working memory in Parkinson's disease.Brain communications · 2022Article
- Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease.Frontiers in psychology · 2021Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeficits in maintaining and manipulating sequential information online can occur even in patients with mild Parkinson's disease. The subthalamic nucleus may play a modulatory role in the neural system for sequential working memory, which also includes the lateral prefrontal cortex.
objectivesThe objective of this study was to investigate neural markers of sequential working memory deficits in patients with de novo Parkinson's disease.
methodsA total of 50 patients with de novo Parkinson's disease and 50 healthy controls completed a digit ordering task during functional magnetic resonance imaging scanning. The task separated the maintenance ("pure recall") and manipulation of sequences ("reorder & recall" vs "pure recall").
resultsIn healthy controls, individual participants' task accuracy was predicted by the regional activation and functional connectivity of the subthalamic nucleus. Healthy participants who showed lower subthalamic nucleus activation and stronger subthalamic nucleus connectivity with the putamen performed more accurately in maintaining sequences ("pure recall"). Healthy participants who showed greater ordering-related subthalamic nucleus activation change exhibited smaller accuracy costs in manipulating sequences ("reorder & recall" vs "pure recall"). Patients performed less accurately than healthy controls, especially in "reorder & recall" trials, accompanied by an overactivation in the subthalamic nucleus and a loss of synchrony between the subthalamic nucleus and putamen. Individual patients' task accuracy was predicted only by the subthalamic nucleus connectivity. The contribution of the subthalamic nucleus activation or activation change was absent. We observed no change in the lateral prefrontal cortex.
conclusionsThe overactivation and weakened functional connectivity of the subthalamic nucleus are the neural markers of sequential working memory deficits in de novo Parkinson's disease. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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