ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2021
Lung function trajectories and bronchial hyperresponsiveness during childhood following severe RSV bronchiolitis in infancy.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Early-life respiratory syncytial virus infection and asthma.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Machine learning reveals immune heterogeneity in recovery-phase samples of pediatric wheezing.Frontiers in pediatrics · 2026Article
- Bronchial hyper-reactivity in young adults after hospitalisation for bronchiolitis in infancy.BMJ open respiratory research · 2025Article
- Retrospective observational study of the influence of the COVID-19 outbreak on infants' hospitalisation for acute bronchiolitis.BMJ open · 2022Observational
- Risk Factors for Lung Function Decline in Pediatric Asthma under Treatment: A Retrospective, Multicenter, Observational Study.Children (Basel, Switzerland) · 2022Article
- Preliminary Evidence on Pulmonary Function after Asymptomatic and Mild COVID-19 in Children.Children (Basel, Switzerland) · 2022Article
- Pulmonary Function and Long-Term Respiratory Symptoms in Children and Adolescents After COVID-19.Frontiers in pediatrics · 2022Article
- RSV Infection in Neonatal Mice Induces Pulmonary Eosinophilia Responsible for Asthmatic Reaction.Frontiers in immunology · 2022Article
- Role of Respiratory Syncytial Virus in Pediatric Pneumonia.Microorganisms · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChildren with severe respiratory syncytial virus (RSV) bronchiolitis in infancy have increased risks of asthma and reduced lung function in later life. There are limited studies on the longitudinal changes of lung function and bronchial hyperreactivity from early to late childhood in infants hospitalized for RSV bronchiolitis.
methodsIn a prospective cohort of 206 children with their first episode of RSV-confirmed bronchiolitis in the first year of life, 122 had spirometry performed at least twice between 5-16 years of age. Methacholine bronchoprovocation was available in 127 and 79 children at 7 and 12 years of age, respectively. Longitudinal changes in FEV
results55% of the study cohort (N = 122) were male, and 55% were Caucasian. During follow-up, longitudinal changes in z-scores for pre- and post-bronchodilator FEV
conclusionsFollowing severe RSV bronchiolitis, there appear to be significant longitudinal changes in pre- and post-bronchodilator lung function during childhood. The study has several limitations including significant dropouts and the lack of a control group and post-bronchodilator measurements. Bronchial hyperreactivity is common in children following severe RSV bronchiolitis; however, it appears to decrease as they enter late childhood.
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