Evidence map›Paper›PMID 33098572›Full record

ArticleBiopolymers2021

6-phenylpyrrolocytosine as a fluorescent probe to examine nucleotide flipping catalyzed by a DNA repair protein.

Delshanee Kotandeniya, Melanie S Rogers, Jenna Fernandez, Sreenivas Kanugula, Robert H E Hudson, Freddys Rodriguez, John D Lipscomb, Natalia Tretyakova

Open access · greenAbstract read
In one paragraph

Article in Biopolymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Isothiazologuanosine (Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Delshanee KotandeniyaDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Melanie S RogersDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-2657-7065
Jenna FernandezDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Sreenivas KanugulaDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Robert H E HudsonDepartment of Chemistry, University of Western Ontario, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-6530-6479
Freddys RodriguezDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
John D LipscombDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-8158-5594
Natalia TretyakovaDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-0621-6860
University of Minnesota · USPennsylvania State University · USWestern University · CA

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
OXYGENASE ENZYME MECHANISMR01GM024689 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LIPSCOMB, JOHN D · 1985 to 2016
$3.8M
Smoking-Induced Epigenetic Changes in the Lung: Role of DNA DemethylationR01CA095039 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2022
$3.6M
Intermediates in O2 Activation by Oxygenases at Non-heme Iron CentersR35GM118030 · NIGMS · UNIVERSITY OF MINNESOTA · PI LIPSCOMB, JOHN D · 2016 to 2020
$2.7M
Training the Next Generation of Chemical BiologistsT32GM132029 · NIGMS · UNIVERSITY OF MINNESOTA · PI Erin Elizabeth Carlson, William Charles Krause Pomerantz · 2019 to 2026
$2.7M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA095039NIGMS NIH HHS R01 GM024689NIGMS NIH HHS R01 GM24689NIGMS NIH HHS R35 GM118030NIGMS NIH HHS T32 GM132029
6 · The paper itself

Abstract

Cellular exposure to tobacco-specific nitrosamines causes formation of promutagenic O

Indexed as

DNA RepairAlkylationBase PairingBiocatalysisCpG IslandsCytidineCytosineDNA AdductsFluorescent DyesKineticsMutagenesis, Site-DirectedO(6)-Methylguanine-DNA MethyltransferasePyrrolesTumor Suppressor Protein p536-phenylpyrrolocytidineCytidineCytosineDNA AdductsFluorescent DyesO(6)-Methylguanine-DNA MethyltransferasePyrrolesTumor Suppressor Protein p53alkylguaninebase-flippingdealkylationfluorescent probetransient kinetics

Identifiers

PMID33098572
PMCPMC7856187
OpenAlexW3094615079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.