Evidence map›Paper›PMID 33098534›Full record

ArticleCancer causes & control : CCC2021

Age at initiation of screening mammography by family history of breast cancer in the breast cancer surveillance consortium.

Danielle D Durham, Megan C Roberts, Carly P Khan, Linn A Abraham, Robert A Smith, Karla Kerlikowske, Diana L Miglioretti

Open access · greenAbstract read
In one paragraph

Article in Cancer causes & control : CCC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Cancer Screening as a Conversation, Not a Checklist: Enhancing Professional Cancer Education Through Narrative Medicine.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Danielle D DurhamDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. danielle_durham@med.unc.edu.ORCID http://orcid.org/0000-0002-8871-589X
Megan C RobertsDivision of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-3434-2773
Carly P KhanPatient-Centered Outcomes Research Institute, Washington, DC, USA.
Linn A AbrahamKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
Robert A SmithPrevention and Early Detection Department, American Cancer Society, Atlanta, GA, USA.
Karla KerlikowskeDepartments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8793-8779
Diana L MigliorettiKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5547-1833
Kaiser Permanente Washington Health Research Institute · USAmerican Cancer Society · USPatient-Centered Outcomes Research Institute · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USUniversity of North Carolina Health Care · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KARLA M KERLIKOWSKE · 2011 to 2026
$52.9M
Vermont Screening Process Documentation UnitU54CA163303 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPRAGUE, BRIAN L · 2011 to 2017
$6.4M
National Cancer Institute (US) P01CA154292NCI NIH HHS P01 CA154292NCI NIH HHS P30 CA016086NCI NIH HHS U54CA16330NCI NIH HHS U54 CA163303Patient-Centered Outcomes Research Institute PCS-1504-30370
6 · The paper itself

Abstract

purposeWomen with a first-degree family history of breast cancer (FHBC) are sometimes advised to initiate screening mammography when they are 10 years younger than the age at which their youngest relative was diagnosed, despite a lack of unambiguous evidence that this is an effective strategy. It is unknown how often this results in women initiating screening earlier (< 40 years) than screening guidelines recommend for average-risk women.

methodsWe examined screening initiation age by FHBC and age at diagnosis of the youngest relative using data collected by the Breast Cancer Surveillance Consortium on 74,838 first screening mammograms performed between 1996 and 2016.

resultsOf the 74,838 women included in the study, nearly 9% reported a FHBC. Approximately 16.8% of women who initiated mammography before 40 years reported a FHBC. More women with a FHBC than without initiated screening < 40 years (48% vs. 23%, respectively). Among women with a FHBC who initiated screening < 40 years, 65% were 10 years younger than the age at which their relative was diagnosed.

conclusionWomen with a first-degree relative diagnosed with breast cancer were more likely to start screening before 40 years than women reporting no FHBC, especially if their relative was diagnosed before 50 years.

Indexed as

AdolescentAdultAgedBreast NeoplasmsEarly Detection of CancerFamilyFemaleHumansMammographyMedical History TakingMiddle AgedYoung AdultBCSCBreast cancer screeningFamily history of breast cancerMammography

Identifiers

PMID33098534
PMCPMC7855994
OpenAlexW3093967800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.