Evidence map›Paper›PMID 33098470›Full record

Trial reportClinical research in cardiology : official journal of the German Cardiac Society2021

Clinical risk predictors in atrial fibrillation patients following successful coronary stenting: ENTRUST-AF PCI sub-analysis.

Andreas Goette, Lars Eckardt, Marco Valgimigli, Thorsten Lewalter, Petra Laeis, Paul-Egbert Reimitz, Rüdiger Smolnik, Wolfgang Zierhut, Jan G Tijssen, Pascal Vranckx

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02866175 (Evaluation of the Safety and Efficacy of an Edoxaban-based Compared to a Vitamin K Antagonist-based Antithrombotic Regimen in Subjects With Atrial Fibrillation Following Successful Percutaneous Coronary Intervention), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02866175 phase3completednot on this map

Evaluation of the Safety and Efficacy of an Edoxaban-based Compared to a Vitamin K Antagonist-based Antithrombotic Regimen in Subjects With Atrial Fibrillation Following Successful Percutaneous Coronary Intervention (PCI) With Stent Placement.

TypeinterventionalSponsorDaiichi Sankyo Europe, GmbH, a Daiichi Sankyo CompanyRan2017 to 2019Enrolled1,506ConditionsAtrial FibrillationArmsEdoxaban, Clopidogrel, Prasugrel, Ticagrelor, Vitamin K antagonist
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Clinical risk predictors in atrial fibrillation patients following successful coronary stenting: ENTRUST-AF PCI sub-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Trial
  2. Article
  3. Article
  4. Article
  5. Atrial fibrillation and stroke prevention: 25 years of research at EP Europace journal.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Review
  6. Risk of myocardial infarction and ischemic stroke in individuals with first-diagnosed paroxysmal vs. non-paroxysmal atrial fibrillation under anticoagulation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  7. Article
  8. Cytotoxic CD8Cells · 2022
    Article
  9. Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2022
    Article
  10. Observational
  11. Article
  12. Article
  13. Review
  14. Anti-thrombotic strategies in patients with atrial fibrillation undergoing PCI.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Andreas GoetteMedizinische Klinik II: Kardiologie Und Intensivmedizin, St. Vincenz-Krankenhaus, Am Busdorf 2, 33098, Paderborn, Germany. andreas.goette@vincenz.de.
Lars EckardtAtrial Fibrillation Network, Munster, Germany.
Marco ValgimigliDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Thorsten LewalterAtrial Fibrillation Network, Munster, Germany.
Petra LaeisDaiichi Sankyo Europe, Munich, Germany.
Paul-Egbert ReimitzDaiichi Sankyo Europe, Munich, Germany.
Rüdiger SmolnikDaiichi Sankyo Europe, Munich, Germany.
Wolfgang ZierhutDaiichi Sankyo Europe, Munich, Germany.
Jan G TijssenDepartment of Cardiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Pascal VranckxDepartment of Cardiology and Intensive Care, Jessa Ziekenhuis, Faculty of Medicine and Life Sciences at the Hasselt University, Hasselt, Belgium.
Daiichi Sankyo (Germany) · DEAtrial Fibrillation NETwork · DEAmsterdam University Medical Centers · NLHasselt University · BESt. Vincenz-Krankenhaus Limburg · DEUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis subgroup analysis of the ENTRUST-AF PCI trial (ClinicalTrials.gov Identifier: NCT02866175; Date of registration: August 2016) evaluated type of AF, and CHA

methodsPatients were randomly assigned after percutaneous coronary intervention (PCI) to either edoxaban (60 mg/30 mg once daily [OD]; n = 751) plus a P2Y

resultsMajor/CRNM bleeding event rates were 20.7%/year and 25.6%/year with edoxaban and warfarin, respectively (HR [95% CI]: 0.83 [0.654-1.047]). The event rates of composite outcome were 7.26%/year and 6.86%/year, respectively (HR [95% CI]): 1.06 [0.711-1.587]), and of overall net clinical benefit were 12.48%/year and 12.80%/year, respectively (HR [(95% CI]: 0.99 [(0.730; 1.343]). Increasing CHA

conclusionAfter PCI in AF patients, increasing CHA

Indexed as

Percutaneous Coronary InterventionStentsAgedAnticoagulantsAtrial FibrillationCoronary Artery DiseaseGermanyHumansIncidencePostoperative ComplicationsRisk AssessmentRisk FactorsAnticoagulantsAtrial fibrillationCHA2DS2-VAScCoronary stentingEdoxabanNOACs

Identifiers

PMID33098470
PMCPMC8166657
OpenAlexW3094324192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.