Evidence map›Paper›PMID 33098448›Full record

ArticlePediatric surgery international2020

Micronutrient deficiencies in pediatric short bowel syndrome: a 10-year review from an intestinal rehabilitation center in China.

Haixia Feng, Tian Zhang, Weihui Yan, Lina Lu, Yijng Tao, Wei Cai, Ying Wang

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Haixia FengDivision of Pediatric Gastroenterology and Nutrition; School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No.1665, KongJiang Road, Shanghai, 200082, China.
Tian ZhangDepartment of Pediatric Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, 200082, China.
Weihui YanDivision of Pediatric Gastroenterology and Nutrition; School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No.1665, KongJiang Road, Shanghai, 200082, China.
Lina LuDivision of Pediatric Gastroenterology and Nutrition; School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No.1665, KongJiang Road, Shanghai, 200082, China.
Yijng TaoDivision of Pediatric Gastroenterology and Nutrition; School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No.1665, KongJiang Road, Shanghai, 200082, China.
Wei CaiShanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Ying WangDivision of Pediatric Gastroenterology and Nutrition; School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No.1665, KongJiang Road, Shanghai, 200082, China. wangying_ssmu@126.com.
XinHua Hospital · CNShanghai Jiao Tong University · CN

Funding

Foundation of Science and Technology Commission of Shanghai Municipality 19495810500Foundation of Shanghai Municipal Health Commission Key weak discipline construction projectFoundation of Shanghai Municipal Health Commission shslczdzk05702National Natural Science Foundation of China 81630039National Natural Science Foundation of China 81974066
6 · The paper itself

Abstract

purposeVitamins and trace elements are essential nutrients for growth and intestinal adaptation in children with short bowel syndrome (SBS). This study aimed to assess micronutrients' status during and after weaning off PN in pediatric SBS.

methodsThis retrospective study evaluated the follow-up of 31 children with SBS between Jan 2010 and Sep 2019. Clinical data were reviewed from the patients' electric medical record. Serum electrolytes, trace elements, vitamin B12, vitamin D, and folate concentrations were collected before and after enteral autonomy.

resultsThirty-one SBS cases were reviewed (median onset age 11 days after birth, 51.6% boys, mean PN duration 4 months, and mean residual small intestine length 58.2 cm). Median duration of follow-up was 10 months (interquartile range [IQR]: 4, 19). The common micronutrient deficiencies were zinc (51.6%), copper (38.7%), vitamin D (32.3%), and phosphorus (25.8%) after the transition to EN. The proportion of patients deficient in vitamin D decreased dramatically from 93.5% to 32.3% (P < 0.001), and serum concentrations of vitamin D increased significantly (27.4 ± 12.3 vs. 60.3 ± 32.9 nmol/l, P = 0.03) after achieving full enteral feeding more than 1 month. Additionally, serum magnesium levels significantly increased (0.76 ± 0.17 vs. 0.88 ± 0.14 mmol/l, P = 0.03). Hemoglobin levels elevated significantly after weaning off PN (104.3 ± 10.7 vs. 117.8 ± 13.7 g/l, P = 0.03).

conclusionsMicronutrient deficiencies remain a common problem in pediatric SBS through intestinal rehabilitation. Therefore, we strongly recommend supplementation of more vitamin D and trace elements (zinc, copper, and phosphorus) under regular monitoring during long-term intestinal rehabilitation.

Indexed as

ChinaComorbidityEnteral NutritionFemaleFollow-Up StudiesHumansInfantInfant, NewbornInfant Nutrition DisordersInpatientsMaleMicronutrientsRehabilitation CentersRetrospective StudiesShort Bowel SyndromeMicronutrientsParenteral nutritionShort bowel syndromeTrace elementsVitamin

Identifiers

PMID33098448
OpenAlexW3094060175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.