ArticleHuman brain mapping2022
Evaluating brain structure traits as endophenotypes using polygenicity and discoverability.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- MUTATE: a human genetic atlas of multiorgan artificial intelligence endophenotypes using genome-wide association summary statistics.Briefings in bioinformatics · 2025Article
- Genetic architecture of the structural connectome.Nature communications · 2024Article
- Syndrome-Specific Neuroanatomical Phenotypes in Girls With Turner and Noonan Syndromes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Principal and independent genomic components of brain structure and function.Genes, brain, and behavior · 2024Article
- Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Molecular psychiatry · 2023Review
- Examining the shared etiology of psychopathology with genome-wide association studies.Physiological reviews · 2023Review
- Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood.Molecular psychiatry · 2022Article
- Infant Visual Brain Development and Inherited Genetic Liability in Autism.The American journal of psychiatry · 2022Article
- Impact of autism genetic risk on brain connectivity: a mechanism for the female protective effect.Brain : a journal of neurology · 2022Article
- Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases.Science (New York, N.Y.) · 2022Article
- Evaluating brain structure traits as endophenotypes using polygenicity and discoverability.Human brain mapping · 2022Article
- A guidance of model selection for genomic prediction based on linear mixed models for complex traits.Frontiers in genetics · 2022Article
- The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping.Human brain mapping · 2022Article
- X-chromosome influences on neuroanatomical variation in humans.Nature neuroscience · 2021Article
- Common genetic variation influencing human white matter microstructure.Science (New York, N.Y.) · 2021Article
- From base pair to brain.Nature neuroscience · 2021Article
- Review
- Multivariate Analysis and Modelling of multiple Brain endOphenotypes: Let's MAMBO!Computational and structural biotechnology journal · 2021Review
- Clinical opportunity awaits at the intersection of genomics and brain imaging.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Human brain structure traits have been hypothesized to be broad endophenotypes for neuropsychiatric disorders, implying that brain structure traits are comparatively "closer to the underlying biology." Genome-wide association studies from large sample sizes allow for the comparison of common variant genetic architectures between traits to test the evidence supporting this claim. Endophenotypes, compared to neuropsychiatric disorders, are hypothesized to have less polygenicity, with greater effect size of each susceptible SNP, requiring smaller sample sizes to discover them. Here, we compare polygenicity and discoverability of brain structure traits, neuropsychiatric disorders, and other traits (91 in total) to directly test this hypothesis. We found reduced polygenicity (FDR = 0.01) and increased discoverability (FDR = 3.68 × 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.