Evidence map›Paper›PMID 33098212›Full record

Trial reportPediatric diabetes2021

Timing of CGM initiation in pediatric diabetes: The CGM TIME Trial.

Margaret L Lawson, Kate C Verbeeten, Jennilea M Courtney, Brenda J Bradley, Karen McAssey, Cheril Clarson, Susan Kirsch, Jacqueline R Curtis, Farid H Mahmud, Christine Richardson and 3 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01295788 (Simultaneous vs Delayed Initiation of REAL-Time Continuous Glucose Monitoring in Children and Adolescents With Type 1 Diabetes Starting Insulin Pump Therapy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01295788 nacompletednot on this map

Simultaneous vs Delayed Initiation of REAL-Time Continuous Glucose Monitoring in Children and Adolescents With Type 1 Diabetes Starting Insulin Pump Therapy

TypeinterventionalSponsorChildren's Hospital of Eastern OntarioRan2011 to 2017Enrolled144ConditionsType 1 DiabetesArmsSimultaneous RT-CGM and Pump Initiation, Delayed Initiation of RT-CGM
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Margaret L LawsonDivision of Endocrinology and Metabolism, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.ORCID 0000-0002-2370-9552
Kate C VerbeetenDivision of Endocrinology and Metabolism, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Jennilea M CourtneyClinical Research Unit, CHEO Research Institute, Ottawa, Ontario, Canada.
Brenda J BradleyClinical Research Unit, CHEO Research Institute, Ottawa, Ontario, Canada.
Karen McAsseyDepartment of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Cheril ClarsonDepartment of Pediatrics, Children's Hospital, London Health Sciences Centre, Lawson Health Research Institute, London, Ontario, Canada.
Susan KirschDepartment of Pediatrics, Markham-Stouffville Hospital, Markham, Ontario, Canada.
Jacqueline R CurtisDivision of Endocrinology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Farid H MahmudDivision of Endocrinology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Christine RichardsonDivision of Endocrinology and Metabolism, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Tammy CooperDivision of Endocrinology and Metabolism, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Jason ChanClinical Research Unit, CHEO Research Institute, Ottawa, Ontario, Canada.
Ken TangClinical Research Unit, CHEO Research Institute, Ottawa, Ontario, Canada.
Agricultural Research Institute of Ontario · CAChildren's Hospital of Eastern Ontario · CAHospital for Sick Children · CALawson Health Research Institute · CAMarkham Stouffville Hospital · CAMcMaster Children's Hospital · CA

Funding

Juvenile Diabetes Research Foundation 80-2010-585
6 · The paper itself

Abstract

objectiveTo determine whether timing of CGM initiation offering low glucose suspend (LGS) affects CGM adherence in children and youth starting insulin pump therapy.

methodsA 5-site RCT of pump-naïve subjects (aged 5-18 years) with type 1 diabetes (T1D) for at least 1 year compared simultaneous pump and CGM initiation offering LGS vs standard pump therapy with CGM initiation delayed for 6 months. Primary outcome was CGM adherence (hours per 28 days) (MiniMed™ Paradigm™ Veo™ system; CareLink Pro™ software) over 6 months after CGM initiation. Secondary outcome HbA1c was measured centrally. Linear mixed-models and ordinary least squares models were fitted to estimate effect of intervention, and covariates baseline age, T1D duration, HbA1c, gender, ethnicity, hypoglycemia history, clinical site, and association between CGM adherence and HbA1c.

resultsThe trial randomized 144/152 (95%) eligible subjects. Baseline mean age was 11.5 ± 3.3(SD) years, T1D duration 3.4 ± 3.1 years, and HbA1c 7.9 ± 0.9%. Six months after CGM initiation, adjusted mean difference in CGM adherence was 62.4 hours per 28 days greater in the Simultaneous Group compared to Delayed Group (P = .007). There was no difference in mean HbA1c at 6 months. However, for each 100 hours of CGM use per 28-day period, HbA1c was 0.39% (95% CI 0.10%-0.69%) lower. Higher CGM adherence was associated with reduced time with glucose >10 mmol/L (P < .001).

conclusionCGM adherence was higher after 6 months when initiated at same time as pump therapy compared to starting CGM 6 months after pump therapy. Greater CGM adherence was associated with improved HbA1c.

Indexed as

Blood Glucose Self-MonitoringInsulin Infusion SystemsAdolescentBlood GlucoseChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHumansHypoglycemic AgentsInsulinMalePatient ComplianceTime FactorsBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinadherencecontinuous glucose monitoringglycemic controlinsulin pump therapysite differences

Identifiers

PMID33098212
PMCPMC7984035
OpenAlexW3094248692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.