Evidence map›Paper›PMID 33098183›Full record

ArticleGlia2021

Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation.

Jelena Medved, William M Wood, Michael D van Heyst, Amin Sherafat, Ju-Young Song, Sagune Sakya, Dennis L Wright, Akiko Nishiyama

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. The Many Lives of an Oligodendrocyte Precursor Cell.Annual review of neuroscience · 2025
    Review
  2. Cleavage of VAMP2/3 Affects Oligodendrocyte Lineage Development in the Developing Mouse Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jelena MedvedDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
William M WoodDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Michael D van HeystDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.
Amin SherafatDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Ju-Young SongDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Sagune SakyaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Dennis L WrightDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.
Akiko NishiyamaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0001-7252-0812
University of Connecticut · USMansfield University · US

Funding

Inflammation and NG2 Cell DifferentiationR01NS073425 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2011 to 2021
$3.3M
NEUROBIOLOGY OF DISEASE TRAINING PROGRAMT32NS007435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PRICE, DONALD L · 1998 to 2003
$711k
Leica TCS SP8 FSU AOBS 405 UV Spectral Confocal MicroscopeS10OD016435 · OD · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2014 to 2014
$456k
Regulation of glial lineage by Olig2R21NS069960 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO, WRIGHT, DENNIS L. · 2010 to 2011
$402k
NIH HHS S10 OD016435NINDS NIH HHS R01 NS073425NINDS NIH HHS R01 NS07435NINDS NIH HHS R21 NS069960NINDS NIH HHS T32 NS007435
6 · The paper itself

Abstract

Oligodendrocyte precursor cells (OPCs), also known as NG2 cells or polydendrocytes, are distributed widely throughout the developing and mature central nervous system. They remain proliferative throughout life and are an important source of myelinating cells in normal and demyelinating brain as well as a source of glioma, the most common type of primary brain tumor with a poor prognosis. OPC proliferation is dependent on signaling mediated by platelet-derived growth factor (PDGF) AA binding to its alpha receptor (PDGFRα). Here, we describe a group of structurally related compounds characterized by the presence of a basic guanidine group appended to an aromatic core that is effective in specifically repressing the transcription of Pdgfra but not the related beta receptor (Pdgfrb) in OPCs. These compounds specifically and dramatically reduced proliferation of OPCs but not that of astrocytes and did not affect signal transduction by PDGFRα. These findings suggest that the compounds could be further developed for potential use in combinatorial treatment strategies for neoplasms with dysregulated PDGFRα function.

Indexed as

Oligodendrocyte Precursor CellsCell ProliferationGuanidineOligodendrogliaReceptor, Platelet-Derived Growth Factor alphaGuanidineReceptor, Platelet-Derived Growth Factor alphagliomaNG2oligodendrocyte precursorPDGF receptorplatelet-derived growth factorproliferation

Identifiers

PMID33098183
PMCPMC7856068
OpenAlexW3094039104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.