ArticleOral diseases2021
Treatment outcomes and related clinical characteristics in patients with burning mouth syndrome.
Article in Oral diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Efficacy of photobiomodulation in reducing pain and improving the quality of life in patients with idiopathic burning mouth syndrome. A systematic review and meta-analysis.Lasers in medical science · 2022Pooled it
- Use of soft intraoral appliance for refractory burning mouth syndrome: an exploratory case series.BMC oral health · 2026Article
- Topical and Mucoadhesive Administration of Capsaicin in the Burning Mouth Syndrome Treatment.Journal of clinical medicine · 2026Article
- Vitamin D as a modulator of pain and inflammation in postmenopausal females with burning mouth syndrome.Journal of oral & facial pain and headache · 2025Article
- Analysis of pain prognosis, medication efficacy, treatment willingness and influencing factors in patients with burning mouth syndrome: a cross-sectional survey.BMC oral health · 2025Article
- Distinctive salivary oral microbiome in patients with burning mouth syndrome depending on pain intensity compared to healthy subjects.Journal of dental sciences · 2025Article
- Relationship between subjective taste sensations and taste strip test in patients with taste disorders with and without burning mouth syndrome.Journal of dental sciences · 2022Article
- Careful use of clonazepam and alpha lipoid acid in burning mouth syndrome treatment.Oral diseases · 2022Article
- Prediction of treatment outcome in burning mouth syndrome patients using machine learning based on clinical data.Scientific reports · 2021Article
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3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the treatment outcomes of medication therapies in patients with burning mouth syndrome (BMS) and to identify the clinical characteristics that may affect the efficacy of prescribed medications.
methodsThis is a retrospective study of 769 patients with oral burning sensations. Of these patients, 420 patients diagnosed as the primary BMS received an "Initial Approach" that involved a detailed explanation about its etiopathophysiology, self-care instruction, and use of an oral lubricant. Neuropathic medications were prescribed for 277 patients who did not respond to the initial approach. Clinical characteristics, prescribed medications, and changes in intensity of oral symptoms were reviewed.
resultsClonazepam was administered as the first-line medication. Alpha-lipoic acid (ALA), gabapentin, and nortriptyline were commonly administered in combination with clonazepam. More than two-thirds of the patients reported a marked improvement in oral symptoms after treatments with combination of neuropathic medications and ALA. The efficacies of the initial approach and clonazepam had significant positive associations with the initial intensity of oral symptoms and significant negative associations with depression.
conclusionsClonazepam therapy in combination with appropriate medications was effective for managing patients with BMS. The initial intensity of oral symptoms and psychological status were significantly associated with treatment outcomes.
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