Evidence map›Paper›PMID 33098150›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2021

MKK7 deficiency in mature neurons impairs parental behavior in mice.

Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D Marth, Josef M Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. MKK7 deficiency in mature neurons impairs parental behavior in mice.Genes to cells : devoted to molecular & cellular mechanisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Tadashi ShinDepartment of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Yuichi HiraokaDepartment of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Tokiwa YamasakiDepartment of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Jamey D MarthCenter for Nanomedicine, Department of Molecular, Cellular and Developmental Biology, SBP Medical Discovery Institute, University of California Santa Barbara, Santa Barbara, CA, USA.
Josef M PenningerIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Masami Kanai-AzumaDepartment of Experimental Animal Model for Human Disease, Center for Experimental Animals, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Kohichi TanakaDepartment of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Satoshi KofujiDepartment of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Hiroshi NishinaDepartment of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID https://orcid.org/0000-0002-6647-7480
Tokyo Medical and Dental University · JPInstitute of Molecular Biotechnology · ATUniversity of California, Santa Barbara · US

Funding

Protein Glycosylation in the Coagulopathy and Inflammation of SepsisP01HL131474 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MARTH, JAMEY · 2016 to 2025
$26.2M
GLYCOSYLTRANSFERASE FUNCTION IN DEVELOPMENT AND DISEASER01DK048247 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMEY MARTH · 1994 to 2026
$9.4M
AMED 42AMED JP18fk0210042AMED JP19fk0210042AMED JP20fk02100Grant-in-Aid for Scientific Research on Innovative Areas JP17H05996Grant-in-Aid for Scientific Research on Innovative Areas JP19H04953Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research JP17H03982Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research JP20H03381NHLBI NIH HHS P01 HL131474NIDDK NIH HHS R01 DK048247NIH HHS DK048247Tokyo Medical and Dental University (TMDU)
6 · The paper itself

Abstract

c-Jun N-terminal kinases (JNKs) are constitutively activated in mammalian brains and are indispensable for their development and neural functions. MKK7 is an upstream activator of all JNKs. However, whether the common JNK signaling pathway regulates the brain's control of social behavior remains unclear. Here, we show that female mice in which Mkk7 is deleted specifically in mature neurons (Mkk7

Indexed as

Maternal BehaviorAnimalsBehavior, AnimalFemaleMAP Kinase Kinase 7MiceMice, Inbred C57BLNeuronsOligodendrogliaMap2k7 protein, mouseMAP Kinase Kinase 7JNKmature neuronMKK7parental behavior

Identifiers

PMID33098150
PMCPMC7839552
OpenAlexW3094130899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.