ArticleJournal of neurology2021
Neurolymphomatosis: a single-center experience of neuromuscular manifestations, treatments, and outcomes.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Impressive FDG PET/CT image of extensive peripheral nervous system involvement for T-lymphoblastic leukemia/lymphoma.European journal of nuclear medicine and molecular imaging · 2026Article
- Clinical Spectrum, Diagnostic Work-up, and Outcomes of Neurolymphomatosis in Lymphoid Malignancies: A 10-Patient Case Series.Blood and lymphatic cancer : targets and therapy · 2026Article
- Efficacy of PR2-based immunotherapy in the treatment of diffuse large B-cell lymphoma-associated neurolymphomatosis: A report on two cases.Annals of hematology · 2025Article
- Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma.Frontiers in oncology · 2025Article
- Neurolymphomatosis secondary to primary central nervous system lymphoma: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Sciatic diffuse large B-cell lymphoma with treatment response to CHOP and radiotherapy.Radiology case reports · 2024Article
- COVID-19 associated Bell's Palsy and lumbosacral neurolymphomatosis in a patient with B-cell lymphoma-Case Report.Spinal cord series and cases · 2023Review
- Utility of nerve ultrasound in the management of primary neurolymphomatosis: Case report and review of the literature.Clinical neurophysiology practice · 2023Article
- Neurolymphomatosis in Recrudescent Diffuse Large B-cell Lymphoma.Asia Oceania journal of nuclear medicine & biology · 2023Article
- Particularities of Neurological Manifestations in Adult T-Cell Leukemia/Lymphoma: Need for a Multidisciplinary Approach-A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
- Neuralgic Amyotrophy as the First Presentation of Lymphoma.Internal medicine (Tokyo, Japan) · 2021Article
- Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness.Yeungnam University journal of medicine · 2021Article
- Update on benign paroxysmal positional vertigo.Journal of neurology · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNeurolymphomatosis (NL) is a disease characterized by the infiltration of malignant lymphocytes into the peripheral nervous system. We report clinical features, radiographic findings, modes of treatment, and outcomes of patients with NL.
methodsWe retrospectively investigated patients with NL. We extracted data, including clinical features, magnetic resolution imaging (MRI),
resultsTen NL patients were identified. All patients reported pain/paresthesia and weakness in the affected area. The MRI scans were abnormal in eight out of nine patients with an enhancement of the spinal nerve root, plexus, peripheral nerve trunk, and cranial nerve. The FDG PET/CT scans were positive in all patients. Radiculopathy or radiculoplexopathy was the most common electrodiagnostic finding. Neurological improvement was observed in only three patients. The condition of the nine patients who underwent multimodality treatments for cancer eventually deteriorated and the patients died.
conclusionsNL should be considered in the differential diagnosis of any type of neuropathy in patients with lymphoma. Because it could be confused with other neuropathies in lymphoma and various musculoskeletal diseases, a high index of suspicion and familiarity with clinical manifestation of NL are key. FDG PET/CT was the most sensitive diagnostic imaging modality to detect relevant neural invasion. The root within the spinal neural foramen was the most frequently affected neural structure. Early diagnosis of this rare neurologic manifestation of lymphoma may improve treatment outcomes.
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