Evidence map›Paper›PMID 33097975›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Comparison of PET imaging of activated fibroblasts and

Ximin Shi, Haiqun Xing, Xiaobo Yang, Fang Li, Shaobo Yao, Jia Congwei, Haitao Zhao, Marcus Hacker, Li Huo, Xiang Li

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05687747 (Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma), which is not on this map. Cited by 71 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 7 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05687747 phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma

TypeinterventionalSponsorNational University Hospital, SingaporeRan2023 to 2026Enrolled100ConditionsHepatocellular CarcinomaArmsRadiolabelled tracer, 68Gallium-FAPI-46 PET/MRI
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 7 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Diagnostic Performance of Radiolabelled FAPI Versus [International journal of molecular sciences · 2025
    Pooled it
  2. Pooled it
  3. Comparison ofFrontiers in oncology · 2023
    Pooled it
  4. Head-to-head comparison ofFrontiers in oncology · 2023
    Pooled it
  5. Pooled it
  6. State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis.European journal of nuclear medicine and molecular imaging · 2021
    Pooled it
  7. Pooled it
  8. Assessment of liver fibrosis and tumor burden in hepatocellular carcinoma using [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  9. Diagnostic performance of [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  10. Trial
  11. Comparative Evaluation of [Molecular imaging and biology · 2026
    Article
  12. Diagnostic value of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  13. Review
  14. Article
  15. Diagnostics (Basel, Switzerland) · 2026
    Article
  16. Article
  17. Clinical comprehensive evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  18. Prognostic and diagnostic value of [European radiology · 2025
    Article
  19. Review
  20. Molecular imaging and biology · 2025
    Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ximin ShiDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Chinese Academy of Medical Science and Peking Union Medical College, 1# Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Haiqun XingDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Chinese Academy of Medical Science and Peking Union Medical College, 1# Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Xiaobo YangDepartment of Hepatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Fang LiDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Chinese Academy of Medical Science and Peking Union Medical College, 1# Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Shaobo YaoDepartment of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Jia CongweiDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haitao ZhaoDepartment of Hepatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Marcus HackerDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Li HuoDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Chinese Academy of Medical Science and Peking Union Medical College, 1# Shuaifuyuan, Dongcheng District, Beijing, 100730, China. huoli@pumch.cn.ORCID http://orcid.org/0000-0003-1216-083X
Xiang LiDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNMedical University of Vienna · ATFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to compare the performance of

methodsWe prospectively assessed 20 patients with suspected intrahepatic lesions. Tumour radiological features, pathology, or follow-up examinations were assessed as ground truth in correlation with PET scans. Semiquantitative analysis was additionally performed by measuring the standardised uptake value (SUV). Tumour-to-liver background ratios (TBR) were calculated and compared between

resultsPrimary intrahepatic tumours, including 16 HCC in 14 patients and 4 ICC in 3 patients with extrahepatic metastases, were determined by histology (n = 14) and clinical examinations (n = 3). Based on visual analysis, 17 patients presented elevated

conclusions

Indexed as

Bile Duct NeoplasmsCarcinoma, HepatocellularLiver NeoplasmsBile Ducts, IntrahepaticFibroblastsFluorodeoxyglucose F18HumansPilot ProjectsPositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesQuinolines68Ga-FAPIFluorodeoxyglucose F18Quinolines18F-FDG68Ga-FAPI-04Fibroblast activating proteinHepatic noduleHepatocellular carcinomaIntrahepatic cholangiocarcinoma

Identifiers

PMID33097975
OpenAlexW3094286842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.