ArticleCommunications biology2020
The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 6 of them syntheses that pooled it.
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Who cites it
159 citing papers in PubMed, 6 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits.American journal of human genetics · 2025Pooled it
- Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction.BMC genomic data · 2025Pooled it
- Multi-ancestry whole genome sequencing analysis of lean body mass.Genome biology · 2025Pooled it
- Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis.Human genomics · 2024Pooled it
- Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study.PloS one · 2024Pooled it
- Insulin Resistance and Blood Pressure Control on Cognitive Outcomes.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Trial
- Linking the dietary inflammation index to sarcopenia in diabetes: mediation by body roundness index and evidence from complementary analyses.European journal of applied physiology · 2026Article
- Shared genetic basis of sarcopenia and osteoporosis: insights from GWAS and multi-omics analyses.Journal of bone and mineral metabolism · 2026Article
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- Association of dietary patterns with the prevalence of rheumatic diseases among older Chinese adults: a national cross-sectional survey.Clinical rheumatology · 2026Article
- Genome-wide association study of sarcopenia index reveals sex-stratified genetic architecture.Biology of sex differences · 2026Article
- Integrative GWAS Catalog Analysis of Proxy-Trait Intersection in Sarcopenia-Related Musculoskeletal Aging with Multi-Criteria Evidence Integration.Life (Basel, Switzerland) · 2026Article
- From Athletic Performance to Functional Ageing: Shared Genetic Architecture, Redox-Inflammatory Pathways and Functional Reserve Across the Life Course-A Narrative Review.Biomedicines · 2026Review
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- Unveiling muscle fatigue: identifying key gene biomarkers and therapeutic targets.Molecular and cellular biochemistry · 2026Article
- Causal Links Between Sleep Duration and Sarcopenia-Related Phenotypes: A Mendelian Randomization and Shared Genetic Mechanism Study.American journal of physical medicine & rehabilitation · 2026Article
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- Mitochondria-Related Genome-Wide Mendelian Randomization Identifies Putatively Genes for Chronic Fatigue.Molecular neurobiology · 2026Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we conducted a genome-wide association study (GWAS) with 450,243 UK Biobank participants to uncover its genetic architecture. A total of 1059 conditionally independent variants from 799 loci were identified at the genome-wide significance level (p < 5 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.