ArticleScientific reports2020
Genomic analysis of European bovine Staphylococcus aureus from clinical versus subclinical mastitis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 83 citations in OpenAlex.
- Lineage-Associated Genomic and Phenotypic Features of Bovine Mastitis-AssociatedMicroorganisms · 2026Article
- Review
- Genetic and Phenotypic Characteristics of FiveAnimals : an open access journal from MDPI · 2026Article
- Assessment of the Microbiological Quality of Raw Milk Sold Through Vending Machines at the Farm Level in Switzerland.Pathogens (Basel, Switzerland) · 2026Article
- Study on Genomic Diversity, Prophage Distribution of Bovine-DerivedMicroorganisms · 2025Article
- Virulence traits, agr typing, multidrug resistance patterns, and biofilm ability of MDR Staphylococcus aureus recovered from clinical and subclinical mastitis in dairy cows.BMC microbiology · 2025Article
- Whole genome sequencing identifies exotoxin and antimicrobial resistance profiles of Staphylococcus aureus from Maine dairy farms.BMC veterinary research · 2025Article
- Clonality, Virulence Genes, and Antimicrobial Resistance of Dairy Ruminants in Mastitic Milk-AssociatedAntibiotics (Basel, Switzerland) · 2025Article
- A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness.Animals : an open access journal from MDPI · 2025Review
- Whole-genome sequencing of bacteria accountable for lactational mastitis in humans combined with an examination of their antibiotic resistance profiles.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Zoonotic transmission of asymptomatic carriageMicrobial genomics · 2024Article
- An Investigation of Virulence Genes ofAnimals : an open access journal from MDPI · 2024Article
- Phenotypic and Molecular Characterization ofMicroorganisms · 2024Article
- Unravelling the complexity of bovine milk microbiome: insights into mastitis through enterotyping using full-length 16S-metabarcoding.Animal microbiome · 2024Article
- UID-Dual Transcriptome Sequencing Analysis of the Molecular Interactions betweenAnimals : an open access journal from MDPI · 2024Article
- Genomic insights ofJournal of veterinary science · 2024Article
- Detection ofAnimals : an open access journal from MDPI · 2024Article
- Staphylococcal mastitis in dairy cows.Frontiers in veterinary science · 2024Review
- Rate of Beta-Lactam Resistance and Epidemiological Features ofVeterinary medicine (Auckland, N.Z.) · 2024Review
- The secretome of Staphylococcus aureus strains with opposite within-herd epidemiological behavior affects bovine mononuclear cell response.Veterinary research · 2023Article
Corrections and comments
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Authors and funding
23 authors at 14 institutions in 9 countries.
Funding
Abstract
Intramammary infections (IMI) with Staphylococcus aureus are a common cause of bovine mastitis and can result in both clinical (CM) or subclinical mastitis (SCM). Although bacterial isolates of S. aureus differ in their virulence potential it is largely unclear which bacterial virulence factors are responsible for increased clinical severity. We performed a genome wide association study and used a generalized linear mixed model to investigate the correlation between gene carriage, lineage and clinical outcome of IMI in a collection of S. aureus isolates from cattle with CM (n = 125) and SCM (n = 151) from 11 European countries. An additional aim was to describe the genetic variation of bovine S. aureus in Europa. The dominant lineages in our collection were clonal complex (CC) 151 (81/276, 29.3%), CC97 (54/276, 19.6%), CC479 (32/276, 11.6%) and CC398 (19/276, 6.9%). Virulence and antimicrobial resistance (AMR) gene carriage was highly associated with CC. Among a selection of nine virulence and AMR genes, CC151, CC479 and CC133 carried more virulence genes than other CCs, and CC398 was associated with AMR gene carriage. Whereas CC151, CC97 were widespread in Europe, CC479, CC398 and CC8 were only found in specific countries. Compared to CC151, CC479 was associated with CM rather than SCM (OR 3.62; 95% CI 1.38-9.50) and the other CCs were not. Multiple genes were associated with CM, but due to the clustering within CC of carriage of these genes, it was not possible to differentiate between the effect of gene carriage and CC on clinical outcome of IMI. Nevertheless, this study demonstrates that characterization of S. aureus CC and virulence genes helps to predict the likelihood of the occurrence of CM following S. aureus IMI and highlights the potential benefit of diagnostics tools to identify S. aureus CC during bovine mastitis.
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