Evidence map›Paper›PMID 33097764›Full record

ArticleScientific reports2020

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism.

Leah C Beauchamp, Victor L Villemagne, David I Finkelstein, Vincent Doré, Ashley I Bush, Kevin J Barnham, Christopher C Rowe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. UsingNeurology · 2023
    Article
  7. Review
  8. Review
  9. Article
  10. Neurochemical Features of Rem Sleep Behaviour Disorder.Journal of personalized medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Leah C BeauchampThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.
Victor L VillemagneDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
David I FinkelsteinThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.
Vincent DoréDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
Ashley I BushThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.
Kevin J BarnhamThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia. kevin.barnham@florey.edu.au.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.
University of Melbourne · AUAustin Health · AUCSIRO Health and Biosecurity · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
NINDS NIH HHS P50 NS053488
6 · The paper itself

Abstract

Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapies relies on early detection of the underlying pathological process, leading to early interventions in the disease phenotype. Healthy (n = 16), REM sleep behavior disorder (RBD) (n = 14), dementia with Lewy bodies (n = 10), and Parkinson's disease (PD) (n = 20) participants underwent

Indexed as

AgedAged, 80 and overBrainCaudate NucleusCorpus StriatumDisease ProgressionEarly DiagnosisFemaleHumansLewy Body DiseaseLongitudinal StudiesMaleNeuropsychological TestsParkinson DiseaseParkinsonian DisordersPositron-Emission TomographySLC18A2 protein, humanVesicular Monoamine Transport Proteins

Identifiers

PMID33097764
PMCPMC7584593
OpenAlexW3094425655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.