Evidence map›Paper›PMID 33097670›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain.

Jonathan Cook, Tyler C Baverstock, Martin B L McAndrew, Phillip J Stansfeld, David I Roper, Allister Crow

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  4. A conserved hub protein required for peptidoglycan remodeling and cell division inProceedings of the National Academy of Sciences of the United States of America · 2025
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  19. Activator-induced conformational changes regulate division-associated peptidoglycan amidases.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Mechanistic insights into the regulation of cell wall hydrolysis by FtsEX and EnvC at the bacterial division site.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jonathan CookSchool of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0003-3690-555X
Tyler C BaverstockSchool of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0003-3033-6376
Martin B L McAndrewSchool of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0001-7338-3119
Phillip J StansfeldSchool of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0001-8800-7669
David I RoperSchool of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0003-0009-621X
Allister CrowSchool of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom; allister.crow@warwick.ac.uk.ORCID 0000-0001-6856-5962
University of Warwick · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M01116X/1Biotechnology and Biological Sciences Research Council BB/P01948X/1Medical Research Council MR/N014294/1Wellcome TrustWellcome Trust 214105/Z/18/Z
6 · The paper itself

Abstract

FtsEX is a bacterial ABC transporter that regulates the activity of periplasmic peptidoglycan amidases via its interaction with the murein hydrolase activator, EnvC. In

Indexed as

ATP-Binding Cassette TransportersBacteriaBacterial ProteinsCell Cycle ProteinsCell DivisionCell MembraneCrystallography, X-RayDNA Mutational AnalysisEndopeptidasesEscherichia coliEscherichia coli ProteinsModels, MolecularMutationN-Acetylmuramoyl-L-alanine AmidasePeriplasmProtein BindingATP-Binding Cassette TransportersBacterial ProteinsCell Cycle ProteinsEndopeptidasesEnvC protein, E coliEscherichia coli ProteinsFtsX protein, bacteriaN-Acetylmuramoyl-L-alanine AmidaseABC transportersbacterial cell divisionpeptidoglycanX-ray crystallography

Identifiers

PMID33097670
PMCPMC7668044
OpenAlexW3094216584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.