ArticleNeurology2021
Contribution of Ictal Source Imaging for Localizing Seizure Onset Zone in Patients With Focal Epilepsy.
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 28 citations in OpenAlex.
- Locating the epileptogenic zone for drug-resistant epilepsy through neuroelectrophysiological brain network topology.Frontiers in neuroscience · 2026Article
- Mapping epileptogenic brain using a unified spatial-temporal-spectral source imaging framework.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Performance of blind source separation in localizing seizure onset from routine scalp-EEG.Journal of neurology · 2025Article
- Deep learning-based EEG source imaging is robust under varying electrode configurations.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Electroencephalographic source imaging of spikes with concurrent high-frequency oscillations is concordant with the clinical ground truth.Epilepsia · 2024Article
- Seizure Sources Can Be Imaged from Scalp EEG by Means of Biophysically Constrained Deep Neural Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Disentanglement of Resting State Brain Networks for Localizing Epileptogenic Zone in Focal Epilepsy.Brain topography · 2024Article
- Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps.Frontiers in neurology · 2024Article
- Deep learning based source imaging provides strong sublobar localization of epileptogenic zone from MEG interictal spikes.NeuroImage · 2023Article
- DeepEZ: A Graph Convolutional Network for Automated Epileptogenic Zone Localization From Resting-State fMRI Connectivity.IEEE transactions on bio-medical engineering · 2023Article
- Ictal source localization from intracranial recordings.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Deep neural networks constrained by neural mass models improve electrophysiological source imaging of spatiotemporal brain dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Imaging the extent and location of spatiotemporally distributed epileptiform sources from MEG measurements.NeuroImage. Clinical · 2022Article
- Exploring the extent of source imaging: Recent advances in noninvasive electromagnetic brain imaging.Current opinion in biomedical engineering · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether seizure onset zone (SOZ) can be localized accurately prior to surgical planning in patients with focal epilepsy, we performed noninvasive EEG recordings and source localization analyses on 39 patients.
methodsIn 39 patients with focal epilepsy, we recorded and extracted 138 seizures and 1,325 interictal epileptic discharges using high-density EEG. We investigated a novel approach for directly imaging sources of seizures and interictal spikes from high-density EEG recordings, and rigorously validated it for noninvasive localization of SOZ determined from intracranial EEG findings and surgical resection volume. Conventional source imaging analyses were also performed for comparison.
resultsIctal source imaging showed a concordance rate of 95% when compared to intracranial EEG or resection results. The average distance from estimation to seizure onset (intracranial) electrodes is 1.35 cm in patients with concordant results, and 0.74 cm to surgical resection boundary in patients with successful surgery. About 41% of the patients were found to have multiple types of interictal activities; coincidentally, a lower concordance rate and a significantly worse performance in localizing SOZ were observed in these patients.
conclusionNoninvasive ictal source imaging with high-density EEG recording can provide highly concordant results with clinical decisions obtained by invasive monitoring or confirmed by resective surgery. By means of direct seizure imaging using high-density scalp EEG recordings, the added value of ictal source imaging is particularly high in patients with complex interictal activity patterns, who may represent the most challenging cases with poor prognosis.
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