ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2021
A Social Affective Neuroscience Model of Risk and Resilience in Adolescent Depression: Preliminary Evidence and Application to Sexual and Gender Minority Adolescents.
Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal Alcohol Exposure and the Risk of Depression in Offspring: a Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Low Emotional Awareness and Altered Frontostriatal Functional Connectivity During Reward Processing Prospectively Predict Depressive Symptoms in At-Risk Youth.Journal of child and adolescent psychopharmacology · 2026Article
- Reduced amygdala habituation to anticipated social rejection in youth with major depressive disorder.Journal of affective disorders · 2026Article
- Interpersonal Contributors to Depression in Sexual Minority Adolescents: An Examination of Exposure to Acute Stressors and Neural Reactivity to Interpersonal Emotional Images.Developmental psychobiology · 2026Article
- Understanding suicide in sexual minority youth: neural reactivity to social cues as a moderating influence.Cognitive, affective & behavioral neuroscience · 2025Article
- Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.Psychiatry research. Neuroimaging · 2025Review
- Depressive symptoms and suicidal ideation in sexual minority adolescents: An examination of social reward responsiveness and support as moderators.Journal of mood and anxiety disorders · 2024Article
- [Path analysis of influencing factors of mental resilience in adolescents with depression].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- It's a balancing act: The ratio of maladaptive (vs. All) emotion regulation strategies is associated with depression.Behaviour research and therapy · 2024Article
- Sleep disturbance and social reward processing as characteristics linking minority victimization and suicidal ideation in youth.Frontiers in neuroscience · 2024Article
- Neural activation to peer acceptance and rejection in relation to concurrent and prospective depression risk in adolescent and pre-adolescent girls.Biological psychology · 2023Article
- The Relationship between Minority Stress and Depressive Symptoms in the LGBTQA Population from Poland.European journal of investigation in health, psychology and education · 2023Article
- Mood Symptom Dimensions and Developmental Differences in Neurocognition in Adolescence.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Diversity, Equity, and Inclusivity in Biological Psychiatry Research.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Medial Prefrontal Cortex Activity to Reward Outcome Moderates the Association Between Victimization Due to Sexual Orientation and Depression in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Utilizing network analysis to understand the structure of depression in Chinese adolescents: Replication with three depression scales.Current psychology (New Brunswick, N.J.) · 2022Article
- Predicting Negative and Positive Affect During COVID-19: A Daily Diary Study in Youths.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2021Article
- Risk and Resilience in Extraordinary Times.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Depression is a disorder of dysregulated affective and social functioning, with attenuated response to reward, heightened response to threat (perhaps especially social threat), excessive focus on negative aspects of the self, ineffective engagement with other people, and difficulty modulating all of these responses. Known risk factors provide a starting point for a model of developmental pathways to resilience, and we propose that the interplay of social threat experiences and neural social-affective systems is critical to those pathways. We describe a model of risk and resilience, review supporting evidence, and apply the model to sexual and gender minority adolescents, a population with high disparities in depression and unique social risk factors. This approach illustrates the fundamental role of a socially and developmentally informed clinical neuroscience model for understanding a population disproportionately affected by risk factors and psychopathology outcomes. We consider it a public health imperative to apply conceptual models to high-need populations to elucidate targets for effective interventions to promote healthy development and enhance resilience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.