ArticleArthritis research & therapy2020
Serum IgE in the clinical features and disease outcomes of IgG4-related disease: a large retrospective cohort study.
Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Risk factors for relapse of IgG4-related disease: a systematic review and meta‑analysis.Clinical rheumatology · 2025Pooled it
- Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review.Clinical oral investigations · 2025Pooled it
- IgG4-related orbital disease - An update.Indian journal of ophthalmology · 2026Review
- Clinical significance of serum IgE levels in IgG4-related ophthalmic disease: a single-centre study.Eye (London, England) · 2026Article
- A Case of IgG4-Related Disease That Mimics an Anterior Mediastinal Malignant Tumour.Respirology case reports · 2026Article
- IgG4-Related Ophthalmic Disease with ProptosisBalkan medical journal · 2025Article
- New Developments in the Treatment of IgG4-Related Disease: A Comprehensive Clinical Approach.Journal of clinical medicine · 2025Review
- Global research trends and emerging focus areas in IgG4-related disease: a bibliometric and visual analysis.Hereditas · 2025Article
- Serum IgE in the clinical features and disease outcomes of anti-interferon-γ autoantibodies syndrome.BMC immunology · 2025Article
- Perception of recurrence risk in patients with IgG4-related disease: a descriptive phenomenological study.Rheumatology advances in practice · 2025Article
- Tumor necrosis factor alpha induced protein 3, interleukin 10, tumor necrosis factor alpha, and interleukin 17 F genes polymorphisms in Algerian patients with rheumatoid arthritis.Molecular biology reports · 2024Article
- Current and future advances in practice: IgG4-related disease.Rheumatology advances in practice · 2024Review
- Implication of allergy and atopy in IgG4-related disease.The World Allergy Organization journal · 2023Review
- Thoracic manifestations of IgG4-related disease.Respirology (Carlton, Vic.) · 2023Review
- TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease.Journal of translational medicine · 2022Article
- Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis.RMD open · 2022Article
- Clinical characteristics and therapeutic response of immunoglobulin G4-related disease: a retrospective study of 127 Chinese patients.Orphanet journal of rare diseases · 2022Article
- The Role of Symptom Duration and Serologic Factors in the Relapse of IgG4-Related Ophthalmic Disease following Surgery: A Retrospective Cohort Study.Disease markers · 2022Article
- [Progress of IgG4 related sino-nasal diseases].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- A Rare Case of Immunoglobulin G4-Related Constrictive Pericarditis Diagnosed Via Multimodality Imaging.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveThe aim of this study was to investigate the role of serum IgE levels in the clinical features and outcomes of IgG4-related disease (IgG4-RD).
methodsWe retrospectively enrolled 459 newly diagnosed IgG4-RD patients with serum IgE examined at baseline from 2012 to 2019 and compared the clinical features between group A (serum IgE level ≤ 60 KU/L) and group B (serum IgE level > 60 KU/L). Subsequently, 312 patients who had been followed up for ≥ 1 year were further selected to evaluate the correlation between serum IgE level and disease outcome.
resultsAt baseline, the serum IgE level was positively correlated with the serum IgG4 level (r = 0.1779, P = 0.0001), eosinophil count (r = 0.3004, P < 0.0001), and serum IgG level (r = 0.2189, P < 0.0001) in IgG4-RD patients. Compared with group A, group B had more patients with allergic diseases (P = 0.004), more organ involvement (P = 0.003), and higher IgG4-RD responder index scores (P = 0.002). During follow-up, group A patients had a higher remission induction rate than group B patients (88.4% vs. 73.6%, P = 0.035), while group B patients had a higher relapse rate than group A patients (29.0% vs. 16.2%, P = 0.039). Multivariate analysis found that a serum IgE level > 125 KU/L at baseline was a risk factor for disease relapse (hazard ratio [HR], 1.894 [95% confidence interval (CI) 1.022-3.508]; P = 0.042). Cox regression analysis showed that elevation of the eosinophil count was a risk factor for relapse in both group A and group B patients (HR, 8.504 [95% CI 1.071-42.511]; P = 0.009; and HR, 2.078 [95% CI 1.277-3.380]; P = 0.003, respectively), and the involvement of the lacrimal gland (HR, 1.756 [95% CI 1.108-2.782]; P = 0.017), submandibular gland (HR, 1.654 [95% CI 1.037-2.639]; P = 0.035), and kidney (HR, 3.413 [95% CI 1.076-10.831]; P = 0.037) were also risk factors for relapse in group B patients.
conclusionIgG4-RD patients with high serum IgE levels at baseline were more likely to have higher disease activity, and baseline high IgE levels were associated with disease relapse.
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