ArticleBMC infectious diseases2020
Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Real-world treatment outcomes of a 6-month fluoroquinolone-containing regimen for isoniazid mono-resistant pulmonary tuberculosis in Korea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Epidemiological analysis and risk factors of recurrent pulmonary tuberculosis in Western Zhejiang Province, China (2007-2024).Frontiers in public health · 2026Article
- Triple-modality diagnosis of paucibacillary pulmonary tuberculosis: comparative accuracy of GeneXpert MTB/RIF, TB-DNA PCR, and T-SPOT.TB.Frontiers in medicine · 2026Article
- Geospatial analysis of shared risks for tuberculosis transmission in an urban cohort.Scientific reports · 2025Article
- Article
- Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis.Journal of orthopaedic surgery and research · 2025Article
- Advancement in diagnostic approaches for latent tuberculosis: distinguishing recent from remote infections.One health outlook · 2025Review
- Construction and Validation of a Nomogram-Based Predictive Model for Acute Kidney Injury Caused by Drug Resistance to Tuberculosis.International journal of general medicine · 2025Article
- Provider fidelity in tuberculosis screening practices among adolescents and adults living with HIV in public health facilities in Tanzania: a cross-sectional evaluation.Frontiers in public health · 2025Article
- Factors associated with time to relapse in pulmonary tuberculosis patients using penalized Cox models.BMC research notes · 2024Article
- Left hand abscess as a paradoxical reaction during treatment of disseminated tuberculosis in immunocompetent patient: case report and review of literature.BMC infectious diseases · 2024Review
- Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis.The Journal of infection · 2024Article
- Decreased IL-1 β Secretion as a Potential Predictor of Tuberculosis Recurrence in Individuals Diagnosed with HIV.Biomedicines · 2024Article
- Clinical and laboratory risk factors for pulmonary tuberculosis recurrence in three pooled Indian cohorts.Frontiers in tuberculosis · 2024Article
- Profile and risk factors of pre-XDR-TB and XDR-TB patients in a national reference hospital for Sumatra region of Indonesia.Narra J · 2023Article
- Post-TB health and wellbeing.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- Recurrence of pulmonary tuberculosis in India: Findings from the 2019-2021 nationwide community-based TB prevalence survey.PloS one · 2023Article
- Cost-Utility Analysis of Molecular Testing for Tuberculosis Diagnosis in Suspected Pulmonary Tuberculosis in Thailand.ClinicoEconomics and outcomes research : CEOR · 2022Article
- Demographic and Clinical Determinants of Tuberculosis and TB Recurrence: A Double-Edged Retrospective Study from Pakistan.Journal of tropical medicine · 2022Article
- Tuberculosis Screening via Chest X-Ray is Financially Burdensome in Previously Independently Living Elective Total Knee Arthroplasty Patients.Spartan medical research journal · 2022Article
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3 authors.
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Abstract
backgroundPeople successfully completing treatment for tuberculosis remain at elevated risk for recurrent disease, either from relapse or reinfection. Identifying risk factors for recurrent tuberculosis may help target post-tuberculosis screening and care.
methodsWe enrolled 500 patients with smear-positive pulmonary tuberculosis in South Africa and collected baseline data on demographics, clinical presentation and sputum mycobacterial cultures for 24-loci mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing. We used routinely-collected administrative data to identify recurrent episodes of tuberculosis occurring over a median of six years after successful treatment completion.
resultsOf 500 patients initially enrolled, 333 (79%) successfully completed treatment for tuberculosis. During the follow-up period 35 patients with successful treatment (11%) experienced a bacteriologically confirmed tuberculosis recurrence. In our Cox proportional hazards model, a 3+ AFB sputum smear grade was significantly associated with recurrent tuberculosis with a hazard ratio of 3.33 (95% CI 1.44-7.7). The presence of polyclonal M. tuberculosis infection at baseline had a hazard ratio for recurrence of 1.96 (95% CI 0.86-4.48).
conclusionOur results indicate that AFB smear grade is independently associated with tuberculosis recurrence after successful treatment for an initial episode while the association between polyclonal M. tuberculosis infection and increased risk of recurrence appears possible.
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