Evidence map›Paper›PMID 33096988›Full record

ArticleBMC neurology2020

Functional connectivity and quality of life in young adults with cerebral palsy: a feasibility study.

Diana Tajik-Parvinchi, Andrew Davis, Sophia Roth, Peter Rosenbaum, Sarah N Hopmans, Aya Dudin, Geoffrey Hall, Jan Willem Gorter, MyStory Study Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Diana Tajik-ParvinchiDepartment of Pediatrics and CanChild, McMaster University, Hamilton, Ontario, L8S 1C7, Canada. dparvinchi@mcmaster.ca.ORCID http://orcid.org/0000-0002-0910-7088
Andrew DavisDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, L8S 1C7, Canada.
Sophia RothDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, L8S 1C7, Canada.
Peter RosenbaumDepartment of Pediatrics and CanChild, McMaster University, Hamilton, Ontario, L8S 1C7, Canada.
Sarah N HopmansDepartment of Pediatrics and CanChild, McMaster University, Hamilton, Ontario, L8S 1C7, Canada.
Aya DudinDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, L8S 1C7, Canada.
Geoffrey HallDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, L8S 1C7, Canada.
Jan Willem GorterDepartment of Pediatrics and CanChild, McMaster University, Hamilton, Ontario, L8S 1C7, Canada.
MyStory Study Group
McMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral Palsy (CP) is a group of disorders that affect the development of movement and posture. CP results from injuries to the immature brain during the prenatal, perinatal, or postnatal stage of development. Neuroimaging research in CP has focused on the structural changes of the brain during early development, but little is known about brain's structural and functional changes during late adolescence and early adulthood, a period in time when individuals experience major changes as they transition into adulthood. The work reported here served as a feasibility study within a larger program of research (MyStory Study). We aimed to determine whether it would be feasible to scan and obtain good quality data without the use of sedation during a resting state condition for functional connectivity (FC) analyses in young adults with CP. Second, we aimed to identify the FC pattern(s) that are associated with depressive mood ratings, indices of pain and fatigue, and quality of life in this group.

methodsResting state functional images were collected from 9 young people with CP (18-29 years). We applied a stringent head motion correction and quality control methods following preprocessing.

resultsWe were able to scan and obtain good quality data without the use of sedation from this group of young individuals with CP who demonstrated a range of gross motor ability. The functional connectivity networks of interest were identified in the data using standard seed regions. Our analyses further revealed that higher well-being scores were associated with higher levels of FC between the Medial Pre-Frontal Cortex and the right Lateral Parietal regions, which are implicated in prosocial and emotion regulations skills. The implications of this association are discussed.

conclusionThe findings of the present study demonstrate that it is feasible to conduct resting state functional connectivity in young adults with CP with different gross motor abilities without the use of sedation. Our results also highlight a neural circuitry that is associated with the self-report of quality of life and emotion regulation. These findings identify these regions/circuitries as important seeds for further investigations into mental health and wellbeing in CP.

Indexed as

AdolescentAdultBrainCerebral PalsyFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNerve NetNeuroimagingQuality of LifeYoung AdultAdultsCerebral palsyfMRIFunctional connectivityResting state

Identifiers

PMID33096988
PMCPMC7583292
OpenAlexW3093544849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.