Evidence map›Paper›PMID 33096928›Full record

ArticleInternational journal of molecular sciences2020

Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma.

Anastasia Makarevic, Carmen Rapp, Steffen Dettling, David Reuss, Christine Jungk, Amir Abdollahi, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende, Rolf Warta

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anastasia MakarevicDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.
Carmen RappDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.
Steffen DettlingDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.
David ReussGerman Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Christine JungkDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.
Amir AbdollahiGerman Cancer Consortium (DKTK), 69120 Heidelberg, Germany.ORCID 0000-0002-8016-5897
Andreas von DeimlingGerman Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Andreas UnterbergDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.
Christel Herold-MendeDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-1915-745X
Rolf WartaDivision of Experimental Neurosurgery, Department of Neurosurgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-2821-4361
Heidelberg University · DEGerman Cancer Research Center · DE

Funding

Deutsche Forschungsgemeinschaft 404521405
6 · The paper itself

Abstract

Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (

Indexed as

AdultAgedAged, 80 and overBrain NeoplasmsFemaleGliomaHumansIsocitrate DehydrogenaseLymphocytes, Tumor-InfiltratingMaleMatched-Pair AnalysisMiddle AgedMutationNeoplasm Recurrence, LocalT-Lymphocytes, CytotoxicTumor MicroenvironmentIsocitrate Dehydrogenaselower-grade gliomaprimary tumorsradiotherapyrecurrent tumorsT-cell infiltrationTissueFAXS

Identifiers

PMID33096928
PMCPMC7590222
OpenAlexW3094286564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.