Evidence map›Paper›PMID 33096888›Full record

ArticleToxins2020

New Insights in

Elisabete Valério, Sara Barreiros, Sara Rodrigues, Maria V Turkina, Vitor M Vasconcelos, Alexandre Campos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elisabete ValérioDepartamento de Saúde Ambiental, Instituto Nacional de Saúde Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal.ORCID 0000-0001-8189-244X
Sara BarreirosDepartamento de Saúde Ambiental, Instituto Nacional de Saúde Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal.
Sara RodriguesDepartamento de Saúde Ambiental, Instituto Nacional de Saúde Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal.
Maria V TurkinaDepartment of Biomedical and Clinical Sciences, Faculty of Medicine and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.
Vitor M VasconcelosCentro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.ORCID 0000-0003-3585-2417
Alexandre CamposCentro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
National Institute of Health Dr. Ricardo Jorge · PTUniversidade do Porto · PTLinköping University · SE

Funding

European Regional Development Fund (ERDF) through the COMPETE e Operational Competitiveness Program and national funds through FCT (Foundation for Science and Technology) grant to E. Valerio (SFRH/BPD/ 75922/2011). Strategic Funding UIDB/04423/2020 and UI : SFRH/BPD/ 75922/2011; UIDB/04423/2020 and UIDP/04423/2020 ; No 823860
6 · The paper itself

Abstract

Microcystins (MCs) are hepatotoxins produced by some cyanobacteria. They are cyclic peptides that inhibit the serine/threonine protein phosphatases (PPs) PP1 and PP2A, especially PP2A. The inhibition of PP2A triggers a series of molecular events, which are responsible for most MC cytotoxic and genotoxic effects on animal cells. It is also known that MCs induce oxidative stress in cells due to the production of reactive oxygen species (ROS). However, a complete characterization of the toxic effects of MCs is still not accomplished. This study aimed to clarify additional molecular mechanisms involved in MC-LR toxicity, using

Indexed as

ProteomicsDNA DamageDNA ReplicationDose-Response Relationship, DrugGene Expression Regulation, FungalMarine ToxinsMicrobial ViabilityMicrocystinsOxidative StressProteomeSaccharomyces cerevisiaeSaccharomyces cerevisiae Proteinscyanoginosin LRMarine ToxinsMicrocystinsProteomeSaccharomyces cerevisiae ProteinsBER genesMicrocystin-LRMTT assaysReal-Time RT-qPCRSaccharomyces cerevisiaeshotgun proteomics

Identifiers

PMID33096888
PMCPMC7594057
OpenAlexW3094071447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.