Evidence map›Paper›PMID 33096835›Full record

ArticleInternational journal of molecular sciences2020

Newly Synthesized Imino-Derivatives Analogues of Resveratrol Exert Inhibitory Effects in Breast Tumor Cells.

Domenico Iacopetta, Rosamaria Lappano, Annaluisa Mariconda, Jessica Ceramella, Maria Stefania Sinicropi, Carmela Saturnino, Marianna Talia, Francesca Cirillo, Fabio Martinelli, Francesco Puoci and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Editorial for the Special Issue "New Drugs for Breast Cancer Treatment".International journal of molecular sciences · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Domenico IacopettaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0001-5179-7118
Rosamaria LappanoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.
Annaluisa MaricondaDepartment of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Jessica CeramellaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.
Maria Stefania SinicropiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0003-2435-8931
Carmela SaturninoDepartment of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-7419-8780
Marianna TaliaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.
Francesca CirilloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.
Fabio MartinelliDepartment of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Francesco PuociDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-5963-6762
Camillo RosanoBiopolymers and Proteomics IRCCS, Ospedale Policlinico San Martino-IST, Largo R. Benzi 10, 16132 Genova, Italy.ORCID 0000-0003-2949-9215
Pasquale LongoDepartment of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Marcello MaggioliniDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.
University of Calabria · ITUniversity of Basilicata · ITUniversity of Salerno · ITOspedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer represents the most frequently diagnosed malignancy in women worldwide. Various therapeutics are currently used in order to halt the progression of breast tumor, even though certain side effects may limit the beneficial effects. In recent years, many efforts have been addressed to the usefulness of natural compounds as anticancer agents due to their low toxicity. Resveratrol, a stilbene found in grapes, berries, peanuts and soybeans, has raised a notable interest for its antioxidant, anti-inflammatory, and antitumor properties. Here, we report the design, the synthesis and the characterization of the anticancer activity of a small series of imino

Indexed as

Antineoplastic AgentsBiological AvailabilityBreast NeoplasmsCell Line, TumorCell ProliferationDNA Topoisomerases, Type IDNA Topoisomerases, Type IIFemaleHEK293 CellsHumansIminesMolecular Docking SimulationPoly-ADP-Ribose Binding ProteinsResveratrolTopoisomerase I InhibitorsAntineoplastic AgentsDNA Topoisomerases, Type IDNA Topoisomerases, Type IIIminesPoly-ADP-Ribose Binding ProteinsResveratrolTOP1 protein, humanTOP2A protein, humanTopoisomerase I Inhibitorsantitumor activityapoptosisbioavailabilitybreast cancerresveratrolresveratrol analoguestopoisomerases

Identifiers

PMID33096835
PMCPMC7589783
OpenAlexW3094309464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.