Evidence map›Paper›PMID 33096770›Full record

ArticleInternational journal of molecular sciences2020

Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake

Tarek Mohamed Abd El-Aziz, Lucie Jaquillard, Sandrine Bourgoin-Voillard, Guillaume Martinez, Mathilde Triquigneaux, Claude Zoukimian, Stéphanie Combemale, Jean-Pascal Hograindleur, Sawsan Al Khoury, Jessica Escoffier and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Peptides for Health Benefits 2020.International journal of molecular sciences · 2022
    Article
  6. Metabolism open · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Tarek Mohamed Abd El-AzizDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.ORCID 0000-0002-3441-9673
Lucie JaquillardSmartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, France.
Sandrine Bourgoin-VoillardPROMETHEE Proteomic Platform, University Grenoble Alpes, LBFA et BEeSy, 38041 Grenoble, France.ORCID 0000-0001-6511-0612
Guillaume MartinezInstitut Pour l'Avancée des Biosciences (IAB), INSERM U1209, CNRS UMR 5309, 38700 La Tronche, France.
Mathilde TriquigneauxSmartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, France.
Claude ZoukimianSmartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, France.
Stéphanie CombemaleSmartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, France.
Jean-Pascal HograindleurInstitut Pour l'Avancée des Biosciences (IAB), INSERM U1209, CNRS UMR 5309, 38700 La Tronche, France.
Sawsan Al KhouryL'institut du thorax, INSERM, CNRS, UNIV NANTES, F-44007 Nantes, France.
Jessica EscoffierInstitut Pour l'Avancée des Biosciences (IAB), INSERM U1209, CNRS UMR 5309, 38700 La Tronche, France.
Sylvie MichellandPROMETHEE Proteomic Platform, University Grenoble Alpes, LBFA et BEeSy, 38041 Grenoble, France.
Philippe BuletInstitut Pour l'Avancée des Biosciences (IAB), INSERM U1209, CNRS UMR 5309, 38700 La Tronche, France.ORCID 0000-0001-9016-265X
Rémy BeroudSmartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, France.
Michel SevePROMETHEE Proteomic Platform, University Grenoble Alpes, LBFA et BEeSy, 38041 Grenoble, France.ORCID 0000-0001-5503-9488
Christophe ArnoultInstitut Pour l'Avancée des Biosciences (IAB), INSERM U1209, CNRS UMR 5309, 38700 La Tronche, France.
Michel De WaardSmartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, France.ORCID 0000-0002-2782-9615
Centre National de la Recherche Scientifique · FRInserm · FRThe University of Texas Health Science Center at San Antonio · US

Funding

Agence Nationale de la Recherche ANR-11-LABX-0015
6 · The paper itself

Abstract

Animal venoms are small natural mixtures highly enriched in bioactive components. They are known to target at least two important pharmacological classes of cell surface receptors: ion channels and G protein coupled receptors. Since sperm cells express a wide variety of ion channels and membrane receptors, required for the control of cell motility and acrosome reaction, two functions that are defective in infertility issues, animal venoms should contain interesting compounds capable of modulating these two essential physiological functions. Herein, we screened for bioactive compounds from the venom of the Egyptian black snake

Indexed as

AnimalsChromatography, Ion ExchangeDisulfidesEgyptElapidaeElapid VenomsHumansMacaca fascicularisMaleMice, Inbred StrainsPeptidesSequence Homology, Amino AcidSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpermatozoaSperm MotilitySperm TailDisulfidesElapid VenomsPeptidesbioactive componentsdrug screening.mass spectrometrypeptide sequencingproteomicsSnake venomsperm motilityWalterinnesia aegyptia

Identifiers

PMID33096770
PMCPMC7594068
OpenAlexW3093698663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.