Evidence map›Paper›PMID 33096754›Full record

ReviewCells2020

Development of Radiotracers for Breast Cancer-The Tumor Microenvironment as an Emerging Target.

Amelie Heesch, Jochen Maurer, Elmar Stickeler, Mohsen Beheshti, Felix M Mottaghy, Agnieszka Morgenroth

Abstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Synthesis of a [Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  4. Review
  5. Article
  6. The Role of PET/CT in Breast Cancer.Diagnostics (Basel, Switzerland) · 2023
    Review
  7. Toxicity Assessment of [Nanomaterials (Basel, Switzerland) · 2022
    Article
  8. Hybrid total-body pet scanners-current status and future perspectives.European journal of nuclear medicine and molecular imaging · 2022
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amelie HeeschDepartment of Nuclear Medicine, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Jochen MaurerDepartment of Obstetrics and Gynecology, University Hospital Aachen (UKA), 52074 Aachen, Germany.
Elmar StickelerDepartment of Obstetrics and Gynecology, University Hospital Aachen (UKA), 52074 Aachen, Germany.
Mohsen BeheshtiDepartment of Nuclear Medicine, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-3918-3812
Felix M MottaghyDepartment of Nuclear Medicine, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-7212-6521
Agnieszka MorgenrothDepartment of Nuclear Medicine, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular imaging plays an increasingly important role in the diagnosis and treatment of different malignancies. Radiolabeled probes enable the visualization of the primary tumor as well as the metastases and have been also employed in targeted therapy and theranostic approaches. With breast cancer being the most common malignancy in women worldwide it is of special interest to develop novel targeted treatments. However, tumor microenvironment and escape mechanisms often limit their therapeutic potential. Addressing tumor stroma associated targets provides a promising option to inhibit tumor growth and angiogenesis and to disrupt tumor tissue architecture. This review describes recent developments on radiolabeled probes used in diagnosis and treatment of breast cancer especially in triple negative type with the focus on potential targets offered by the tumor microenvironment, like tumor associated macrophages, cancer associated fibroblasts, and endothelial cells.

Indexed as

Tumor MicroenvironmentBreast NeoplasmsCancer-Associated FibroblastsFemaleHumansModels, BiologicalNuclear MedicineRadiopharmaceuticalsRadiopharmaceuticalsbreast cancermolecular imagingradiotracertargeted treatmenttumor microenvironment

Identifiers

PMID33096754
PMCPMC7590199

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.