Evidence map›Paper›PMID 33096734›Full record

ArticleMolecules (Basel, Switzerland)2020

Jinkyung Lee, Sun-Hee Ahn, Zhihao Chen, Sohi Kang, Dong Kyu Choi, Changjong Moon, Sang Hyun Min, Byung-Ju Park, Tae-Hoon Lee

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jinkyung LeeDepartment of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0003-1613-6490
Sun-Hee AhnDepartment of Bio-Health Research Center, Korea Photonics Technology Institute (KOPTI), Gwangju 61007, Korea.
Zhihao ChenDepartment of Molecular Medicine (BK21plus), Chonnam National University Graduate School, Gwangju 61186, Korea.ORCID 0000-0002-8433-5400
Sohi KangDepartment of Veterinary Anatomy, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Korea.
Dong Kyu ChoiNew Drug Development Center, DGMIF, 80 Chumbok-ro, Dong-gu, Daegu 41061, Korea.
Changjong MoonDepartment of Veterinary Anatomy, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0003-2451-0374
Sang Hyun MinNew Drug Development Center, DGMIF, 80 Chumbok-ro, Dong-gu, Daegu 41061, Korea.
Byung-Ju ParkDepartment of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Tae-Hoon LeeDepartment of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Chonnam National University · KRDaegu-Gyeongbuk Medical Innovation Foundation · KRKorea Photonics Technology Institute · KR

Funding

National Research Foundation 2016M3A9B6903087; 2019R1A2C1084080
6 · The paper itself

Abstract

Osteoclasts are large, multinucleated cells responsible for bone resorption and are induced in response to the regulatory activity of receptor activator of nuclear factor-kappa B ligand (RANKL). Excessive osteoclast activity causes pathological bone loss and destruction. Many studies have investigated molecules that specifically inhibit osteoclast activity by blocking RANKL signaling or bone resorption. In recent years, we screened compounds from commercial libraries to identify molecules capable of inhibiting RANKL-induced osteoclast differentiation. Consequently, we reported some compounds that are effective at attenuating osteoclast activity. In this study, we found that

Indexed as

OsteoporosisOvariectomyAnimalsCell DifferentiationCell ProliferationCell SurvivalDose-Response Relationship, DrugFemaleMiceMice, Inbred C57BLOsteoclastsStructure-Activity Relationshipbone lossbone resorptionNAPMAosteoclastosteoporosisovariectomy

Identifiers

PMID33096734
PMCPMC7587973
OpenAlexW3094461282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.