Evidence map›Paper›PMID 33096672›Full record

ArticleInternational journal of molecular sciences2020

Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle.

Daniele Lettieri-Barbato, Giuseppina Minopoli, Rocco Caggiano, Rossella Izzo, Mariarosaria Santillo, Katia Aquilano, Raffaella Faraonio

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Dietary restriction in senolysis and prevention and treatment of disease.Critical reviews in food science and nutrition · 2024
    Review
  11. Oxidative stress and food as medicine.Frontiers in nutrition · 2024
    Review
  12. Article
  13. Insulin and aging - a disappointing relationship.Frontiers in endocrinology · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniele Lettieri-BarbatoDepartment of Biology, University of Rome Tor Vergata, via della Ricerca Scientifica, 00133 Rome, Italy.
Giuseppina MinopoliDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", via Pansini, 80131 Naples, Italy.
Rocco CaggianoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", via Pansini, 80131 Naples, Italy.ORCID 0000-0003-3163-8560
Rossella IzzoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", via Pansini, 80131 Naples, Italy.ORCID 0000-0001-5785-5016
Mariarosaria SantilloDepartment of Clinical Medicine and Surgery, Physiology Nutrition Unit, Federico II University of Naples, 80131 Naples, Italy.
Katia AquilanoDepartment of Biology, University of Rome Tor Vergata, via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0002-5905-9870
Raffaella FaraonioDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", via Pansini, 80131 Naples, Italy.ORCID 0000-0002-6563-8158
University of Naples Federico II · ITUniversity of Rome Tor Vergata · IT

Funding

POR Campania FESR 2014-2020 SATIN grant FESR 2014-2020
6 · The paper itself

Abstract

A common metabolic condition for living organisms is starvation/fasting, a state that could play systemic-beneficial roles. Complex adaptive responses are activated during fasting to help the organism to maintain energy homeostasis and avoid nutrient stress. Metabolic rearrangements during fasting cause mild oxidative stress in skeletal muscle. The nuclear factor erythroid 2-related factor 2 (Nrf2) controls adaptive responses and remains the major regulator of quenching mechanisms underlying different types of stress. Here, we demonstrate a positive role of fasting as a protective mechanism against oxidative stress in skeletal muscle. In particular, by using in vivo and in vitro models of fasting, we found that typical Nrf2-dependent genes, including those controlling iron (e.g.,

Indexed as

AnimalsAntioxidantsFastingGene Expression RegulationGlutathioneLipid PeroxidationMaleMalondialdehydeMice, Inbred C57BLMuscle, SkeletalNF-E2-Related Factor 2Oxidative StressReactive Oxygen SpeciesAntioxidantsGlutathioneMalondialdehydeNfe2l2 protein, mouseNF-E2-Related Factor 2Reactive Oxygen Specieslipid peroxidesmetabolismNrf2nutrient restrictionoxidative stress

Identifiers

PMID33096672
PMCPMC7589317
OpenAlexW3094356563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.