Evidence map›Paper›PMID 33096661›Full record

ArticleNutrients2020

Green Tomato Extract Prevents Bone Loss in Ovariectomized Rats, a Model of Osteoporosis.

Farida S Nirmala, Hyunjung Lee, Ji-Sun Kim, Taeyoul Ha, Chang Hwa Jung, Jiyun Ahn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Phytochemical and Biological Biodiversity of Tomato (Mini reviews in medicinal chemistry · 2025
    Review
  3. Review
  4. Bone morphogenetic protein 4 is involved in cadmium-associated bone damage.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Farida S NirmalaDepartment of Food Biotechnology, University of Science and Technology, Daejeon 305350, Korea.
Hyunjung LeeResearch Group of Natural Material and Metabolism, Korea Food Research Institute, Wanju 55365, Korea.
Ji-Sun KimResearch Group of Natural Material and Metabolism, Korea Food Research Institute, Wanju 55365, Korea.
Taeyoul HaDepartment of Food Biotechnology, University of Science and Technology, Daejeon 305350, Korea.ORCID 0000-0001-7583-9490
Chang Hwa JungDepartment of Food Biotechnology, University of Science and Technology, Daejeon 305350, Korea.ORCID 0000-0002-1076-750X
Jiyun AhnDepartment of Food Biotechnology, University of Science and Technology, Daejeon 305350, Korea.
Korea Food Research Institute · KRKorea University · KRKorea University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although drug therapies are available for postmenopausal osteoporosis, these drugs are not free of side effects and long-term adherence to them are low. A safe and effective nutritional approach to counter postmenopausal osteoporosis is an important research goal. We fed ovariectomized (OVX) Sprague-Dawley rats a diet supplemented with 1% or 2% green tomato extract (GTE). After 12 weeks, micro-computed tomography scans revealed that GTE supplementation effectively prevented distal femur bone loss. This prevention was due to improved bone formation and suppressed bone resorption as observed by the regulation of osteoblast and osteoclast activities. GTE supplementation also improved bone formation through Bmp2-Smad 1/5/8-Runx2 signaling, while bone resorption was regulated by the receptor activator of nuclear factor kappa-B (RANKL)/osteoprogeterin (OPG) pathway. These results suggest that GTE supplementation prevents severe postmenopausal bone loss by maintaining the regulation of bone homeostasis in OVX rats. GTE as a diet supplement might be a potential novel alternative for the prevention of postmenopausal osteoporosis.

Indexed as

Solanum lycopersicumAnimalsBone DensityBone Morphogenetic Protein 2Bone ResorptionCore Binding Factor Alpha 1 SubunitDisease Models, AnimalFemaleHumansOsteogenesisOsteoporosis, PostmenopausalOsteoprotegerinOvariectomyPhytotherapyPlant ExtractsRANK LigandBmp2 protein, ratBone Morphogenetic Protein 2Core Binding Factor Alpha 1 SubunitOsteoprotegerinPlant ExtractsRANK LigandRunx2 protein, ratSmad Proteins, Receptor-RegulatedtomatidineTomatinebone homeostasisgreen tomatoesnutritional supplementpostmenopausal osteoporosis

Identifiers

PMID33096661
PMCPMC7589907
OpenAlexW3094188680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.