Evidence map›Paper›PMID 33096655›Full record

ReviewBiomolecules2020

Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules.

Catherine M Cahill, Rozaleen Aleyadeh, Jin Gao, Changning Wang, Jack T Rogers

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Catherine M CahillNeurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Rozaleen AleyadehWeill Cornell Medicine-Qatar, Qatar Foundation, Doha 24144, Qatar.
Jin GaoDepartment of Clinical Psychology, Qilu Hospital of Shandong University, Qingdao 266011, China.
Changning WangAthinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Jack T RogersNeurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Athinoula A. Martinos Center for Biomedical Imaging · USHarvard University · USMassachusetts General Hospital · USQilu Hospital of Shandong University · CNWeill Cornell Medical College in Qatar · QA

Funding

Post Transcriptional Control of hemorrhagic iron damage.R21NS077079 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROGERS, JACK T · 2012 to 2013
$458k
RNA Targeted Screens of the Prion 5'UTRR21NS064853 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROGERS, JACK T · 2008 to 2010
$270k
MLSN Screen of the PD Alpha Synuclein 5'UTRR21NS059434 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROGERS, JACK T · 2007 to 2008
$263k
NINDS NIH HHS R21 NS059434NINDS NIH HHS R21 NS064853NINDS NIH HHS R21 NS077079
6 · The paper itself

Abstract

Alpha-synuclein (α-Syn) is a 140-amino acid (aa) protein encoded by the Synuclein alpha SNCA gene. It is the synaptic protein associated with Parkinson's disease (PD) and is the most highly expressed protein in the Lewy bodies associated with PD and other alpha synucleopathies, including Lewy body dementia (LBD) and multiple system atrophy (MSA). Iron deposits are present in the core of Lewy bodies, and there are reports suggesting that divalent metal ions including Cu

Indexed as

5' Untranslated RegionsAlcoholismalpha-SynucleinBrainGene Expression RegulationHumansLewy BodiesNeuronsParkinson DiseaseSmall Molecule Libraries5' Untranslated Regionsalpha-SynucleinSmall Molecule LibrariesSNCA protein, humanalcoholalpha synucleiniron homeostasissmall molecules

Identifiers

PMID33096655
PMCPMC7589448
OpenAlexW3094139784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.