Evidence map›Paper›PMID 33096634›Full record

ReviewInternational journal of molecular sciences2020

Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer.

Luca Colucci-D'Amato, Luisa Speranza, Floriana Volpicelli

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06718231 (Transcutaneous Electrical Acupoint Stimulation Alleviate Postoperative Depression in Video-assisted Thoracoscopic Surgery), which is not on this map. Cited by 515 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
515citing papers in PubMed, 15 pooled it
39.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06718231 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Transcutaneous Electrical Acupoint Stimulation Alleviate Postoperative Depression in Video-assisted Thoracoscopic Surgery: a Randomized Controlled Trial

TypeinterventionalSponsorFuling Central Hospital of Chongqing CityRan2024 to 2026Enrolled120ConditionsDepression After Video-assisted Thoracoscopic SurgeryArmsTranscutaneous electrical acupoint stimulation, Sham-TAES
3 · Its place in the literature

Who cites it

515 citing papers in PubMed, 15 syntheses or guidelines pooled it, 905 citations in OpenAlex.

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455 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Luca Colucci-D'AmatoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.ORCID 0000-0001-9363-6611
Luisa SperanzaDepartment of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA.
Floriana VolpicelliDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-0618-5504
Albert Einstein College of Medicine · USUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin receptor kinase B (TrkB) and the low affinity p75 neurotrophin receptor (p75NTR). BDNF plays an important role in proper growth, development, and plasticity of glutamatergic and GABAergic synapses and through modulation of neuronal differentiation, it influences serotonergic and dopaminergic neurotransmission. BDNF acts as paracrine and autocrine factor, on both pre-synaptic and post-synaptic target sites. It is crucial in the transformation of synaptic activity into long-term synaptic memories. BDNF is considered an instructive mediator of functional and structural plasticity in the central nervous system (CNS), influencing dendritic spines and, at least in the hippocampus, the adult neurogenesis. Changes in the rate of adult neurogenesis and in spine density can influence several forms of learning and memory and can contribute to depression-like behaviors. The possible roles of BDNF in neuronal plasticity highlighted in this review focus on the effect of antidepressant therapies on BDNF-mediated plasticity. Moreover, we will review data that illustrate the role of BDNF as a potent protective factor that is able to confer protection against neurodegeneration, in particular in Alzheimer's disease. Finally, we will give evidence of how the involvement of BDNF in the pathogenesis of brain glioblastoma has emerged, thus opening new avenues for the treatment of this deadly cancer.

Indexed as

AnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorBrain NeoplasmsDepressionGenes, Tumor SuppressorHumansMicroRNAsNeurodegenerative DiseasesNeuronal PlasticityNeuroprotective AgentsOncogenesAntidepressive AgentsBDNF protein, humanBrain-Derived Neurotrophic FactorMicroRNAsNeuroprotective AgentsBDNFdepressionglioblastomamiRNAsneurodegenerationneurogenesissynaptic plasticity

Identifiers

PMID33096634
PMCPMC7589016
OpenAlexW3094053673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.