Evidence map›Paper›PMID 33096612›Full record

ArticleBrain sciences2020

Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity.

Abdelnaser A Badawy, Rasha Elghaba, Mohamed Soliman, Abdelaziz M Hussein, Sana A AlSadrah, Amira Awadalla, Osama A Abulseoud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Abdelnaser A BadawyDepartment of Biochemistry, Faculty of Medicine, Northern Border University, Arar 73213, Saudi Arabia.
Rasha ElghabaDepartment of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Mohamed SolimanDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar 73213, Saudi Arabia.
Abdelaziz M HusseinDepartment of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-0239-175X
Sana A AlSadrahDepartment of Preventive Medicine, Governmental Hospital Khobar, Health Centers in Khobar, Ministry of Health, Khobar 34446, Saudi Arabia.ORCID 0000-0002-1254-3542
Amira AwadallaCenter of Excellence and Cancer Genome, Mansoura Urology and Nephrology Center, Mansoura 35516, Egypt.
Osama A AbulseoudNeuroimaging Research Branch, IRP, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224, USA.
Mansoura University · EGNorthern Border University · SANational Institutes of Health · US

Funding

Deanship of the Scientific Research in Northern Border University MED-2018-3-9-F-7894 (AAB)
6 · The paper itself

Abstract

Asymptomatic valproic acid (VPA)-induced hyperammonemia in the absence of liver impairment is fairly common. However, the underlying mechanisms through which VPA causes elevation in plasma ammonia (NH

Indexed as

ammoniacerebellumglutamine synthetasehyperammonemiamechanismprefrontal cortexstriatumvalproic acid

Identifiers

PMID33096612
PMCPMC7589689
OpenAlexW3093936946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.