Evidence map›Paper›PMID 33096432›Full record

ReviewBiosensors & bioelectronics2021

Recent advances in graphene-based nanobiosensors for salivary biomarker detection.

Riccardo Goldoni, Marco Farronato, Stephen Thaddeus Connelly, Gianluca Martino Tartaglia, Woon-Hong Yeo

Abstract readReview
In one paragraph

Review in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Riccardo GoldoniGeorge W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Atlanta, GA, 30332, USA; School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Marco FarronatoDepartment of Medicine, Surgery, and Dentistry, Università Degli Studi di Milano, Milan, Italy; Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Italy.
Stephen Thaddeus ConnellyDepartment of Oral & Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA.
Gianluca Martino TartagliaDepartment of Medicine, Surgery, and Dentistry, Università Degli Studi di Milano, Milan, Italy; Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Italy.
Woon-Hong YeoGeorge W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Atlanta, GA, 30332, USA; Wallace H. Coulter Department of Biomedical Engineering, Parker H. Petit Institute for Bioengineering and Biosciences, Atlanta, GA, 30332, USA; Center for Human-Centric Interfaces and Engineering, Neural Engineering Center, Institute for Materials, Institute for Robotics and Intelligent Machines, Georgia Institute of Technology, Atlanta, GA, 30332, USA. Electronic address: whyeo@gatech.edu.

Funding

Developing an imperceptible electroencephalography at-home sleep monitoring system for cognitive and clinical researchR21AG064309 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI DUARTE, AUDREY, YEO, WOON-HONG · 2020 to 2020
$421k
NIA NIH HHS R21 AG064309
6 · The paper itself

Abstract

As biosensing research is rapidly advancing due to significant developments in materials, chemistry, and electronics, researchers strive to build cutting-edge biomedical devices capable of detecting health-monitoring biomarkers with high sensitivity and specificity. Biosensors using nanomaterials are highly promising because of the wide detection range, fast response time, system miniaturization, and enhanced sensitivity. In the recent development of biosensors and electronics, graphene has rapidly gained popularity due to its superior electrical, biochemical, and mechanical properties. For biomarker detection, human saliva offers easy access with a large variety of analytes, making it a promising candidate for its use in point-of-care (POC) devices. Here, we report a comprehensive review that summarizes the most recent graphene-based nanobiosensors and oral bioelectronics for salivary biomarker detection. We discuss the details of structural designs of graphene electronics, use cases of salivary biomarkers, the performance of existing sensors, and applications in health monitoring. This review also describes current challenges in materials and systems and future directions of the graphene bioelectronics for clinical POC applications. Collectively, the main contribution of this paper is to deliver an extensive review of the graphene-enabled biosensors and oral electronics and their successful applications in human salivary biomarker detection.

Indexed as

Biosensing TechniquesGraphiteNanostructuresBiomarkersElectronicsHumansBiomarkersGraphiteBioelectronicsGrapheneNanobiosensorsSalivary biomarkersWearables

Identifiers

PMID33096432
PMCPMC7666013

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.