ArticleJournal of pain and symptom management2021
Subjective Toxicity Profiles of Children in Treatment for Cancer: A New Guide to Supportive Care?
Article in Journal of pain and symptom management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The safety and efficacy of chimeric antigen receptor-T cell therapy in solid malignancies: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Smart Pediatric Oncology Tracker of Symptoms (SPOTS), a Web-Based Interface for the Pediatric PRO-CTCAE: Development and Usability Study.JMIR formative research · 2026Article
- Defining and measuring tolerability in pediatric, adolescent, and young adult oncology: The essential voices.Cancer · 2025Review
- Advancing Global Cancer Symptom Science: Insights and Strategies From the Inaugural Cancer Symptom Science Expert Meeting.Oncology nursing forum · 2025Article
- Advancing Global Cancer Symptom Science: Insights and Strategies from the Inaugural Cancer Symptom Science Expert Meeting.Seminars in oncology nursing · 2025Article
- Applying latent profile analysis to identify adolescents and young adults with chronic conditions at risk for poor health-related quality of life.Journal of biopharmaceutical statistics · 2025Article
- Agreement and disagreement between child-caregiver symptom and function reports in pediatric oncology.Pediatric blood & cancer · 2024Article
- Health-related quality of life profiles in adolescents and young adults with chronic conditions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Patient-reported outcome measures in children, adolescents, and young adults with palliative care needs-a scoping review.BMC palliative care · 2023Article
- Quality of Life in Adolescents and Young Adults: The Role of Symptom Burden.Journal of pain and symptom management · 2022Observational
- Metabolites Associated With Fatigue and Physical Activity in Childhood Cancer.Biological research for nursing · 2022Article
- The Symptom Experience in Pediatric Cancer: Current Conceptualizations and Future Directions.Current oncology reports · 2022Review
- Profile Comparison of Patient-Reported and Proxy-Reported Symptoms in Pediatric Patients With Cancer Receiving Chemotherapy.JAMA network open · 2022Article
- The predictive trifecta? Fatigue, pain, and anxiety severity forecast the suffering profile of children with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Profiles of Symptom Suffering and Functioning in Children and Adolescents Receiving Chemotherapy.Cancer nursingArticle
- Exploring Inflammation and Stress as Biological Correlates of Symptoms in Children With Advanced Cancer: A Longitudinal Feasibility Study.Journal of pediatric hematology/oncology nursingArticle
- Symptoms, Physical Activity, and Biomarkers in Children at the End of Leukemia Maintenance Therapy.Journal of pediatric hematology/oncology nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
contextChildren and adolescents with cancer experience treatment-related, subjective adverse events (AEs). Identifying distinct groups of patients who predictably experience higher prevalence of AEs could guide patient care.
objectivesStudy aims were to 1) identify groups of children and adolescents reporting AEs using the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (Ped-PRO-CTCAE); 2) determine whether demographic and clinical characteristics predict AE group membership; and 3) examine whether AE group membership was related to the distal outcome of psychological stress.
methodsFour hundred seventy-seven patients self-reported AEs via the Ped-PRO-CTCAE at T1 (beginning of treatment) and the PROMIS Pediatric Psychological Stress measure at T2 (7-28 days later). Latent class analysis was conducted to identify groups of patients and the relationships of the groups with demographic and clinical characteristics, and with stress.
resultsThree distinct a priori unknown AE groups were identified (high AE prevalence, moderate AE prevalence, and low AE prevalence). Females, blacks, patients with high psychological stress, and patients more recently diagnosed were more likely to be in the high AE prevalence group. Gender, age, race, and time since diagnosis were associated with psychological stress.
conclusionChildren with cancer are heterogeneous in experiencing subjective AEs. Gender, race, and time since diagnosis were significantly associated with higher subjective AE prevalence that may lead to psychological stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.