ArticleJournal of pain and symptom management2021
Mortality Risk for Patients With Stage IV Cancer and Acute Illness Hospitalization.
Article in Journal of pain and symptom management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Red blood cell distribution width-to-albumin ratio as a novel predictor for mortality in breast cancer patients admitted to ICU: a retrospective analysis using MIMIC-IV 3.1.BMC medical informatics and decision making · 2026Article
- Racial disparities in the frequency and timing of code status orders among women with breast cancer.BMC cancer · 2024Article
- Do-Not-Resuscitate Orders and Outcomes for Patients with Pancreatic Cancer.Journal of pancreatic cancer · 2022Article
- Pre-Post Evaluation of Collaborative Oncology Palliative Care for Patients With Stage IV Cancer.Journal of pain and symptom management · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
contextCancer prognosis data often come from clinical trials which exclude patients with acute illness.
objectivesFor patients with Stage IV cancer and acute illness hospitalization to 1) describe predictors of 60-day mortality and 2) compare documented decision-making for survivors and decedents.
methodsInvestigators studied a consecutive prospective cohort of patients with Stage IV cancer and acute illness hospitalization. Structured health record and obituary reviews provided data on 60-day mortality (outcome), demographics, health status, and treatment; logistic regression models identified mortality predictors.
resultsFour hundred ninety-two patients with Stage IV cancer and acute illness hospitalization had median age of 60.2 (51% female, 38% minority race/ethnicity); 156 (32%) died within 60 days, and median survival for decedents was 28 days. Nutritional insufficiency (odds rato [OR] 1.83), serum albumin (OR 2.15 per 1.0 g/dL), and hospital days (OR 1.04) were associated with mortality; age, gender, race, cancer, and acute illness type were not predictive. On admission, 79% of patients had orders indicating Full Code. During 60-day follow-up, 42% of patients discussed goals of care. Documented goals of care discussions were more common for decedents than survivors (70% vs. 28%, P < 0.001), as were orders for do not resuscitate/do not intubate (68% vs. 24%, P < 0.001), stopping cancer-directed therapy (29% vs. 10%, P < 0.001), specialty Palliative Care (79% vs. 44%, P < 0.001), and Hospice (68% vs. 14%, P < 0.001).
conclusionAcute illness hospitalization is a sentinel event in Stage IV cancer. Short-term mortality is high; nutritional decline increases risk. For patients with Stage IV cancer, acute illness hospitalization should trigger goals of care discussions.
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