Evidence map›Paper›PMID 33096134›Full record

ArticleJournal of the American Academy of Dermatology2021

Clinical size is a poor predictor of invasion in melanoma of the lentigo maligna type.

Cristian Navarrete-Dechent, Saud Aleissa, Karen Connolly, Brian P Hibler, Stephen W Dusza, Anthony M Rossi, Erica Lee, Kishwer S Nehal

Abstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Dermoscopy Relevance in Eyelid Lentigo Maligna Melanoma.Dermatology practical & conceptual · 2024
    Article
  5. Overdiagnosis of Melanoma: Is It a Real Problem?Dermatology practical & conceptual · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristian Navarrete-DechentDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Dermatology, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Saud AleissaDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Karen ConnollyDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Brian P HiblerDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Stephen W DuszaDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Anthony M RossiDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.
Erica LeeDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Kishwer S NehalDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address: nehalk@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThere are no well-defined clinical factors to predict the risk of occult invasion in melanoma of the lentigo maligna type (LM) before complete histopathologic analysis.

objectiveTo evaluate whether clinical size was a predictor of invasion in LM and subclinical extension.

methodsConsecutive cases of LM were recorded in a prospectively maintained database from 2006 to 2019. Patient and tumor data were recorded during initial evaluation. The LM clinical area was calculated in square millimeters (length × width). All patients were treated with staged excision.

resultsWe included 600 patients. The mean age was 65.9 years (standard deviation, 12.3; range, 27-95 years); 62.8% (n = 377) were men. The mean LM clinical area was 128.32 mm LIMITATIONS: The study was performed in a tertiary cancer center with possible referral bias and more complex cases.

conclusionsLM can present with variable clinical size, which may correlate with subclinical extension; however, the presence of invasion is not well estimated by LM clinical area.

Indexed as

Mohs SurgeryAdultAgedAged, 80 and overBiopsyFemaleHumansHutchinson's Melanotic FreckleMaleMargins of ExcisionMiddle AgedNeoplasm InvasivenessPrognosisProspective StudiesSkin NeoplasmsTumor BurdenBreslowhead and neckinvasionlentigo malignalentigo maligna melanomamelanomaprognosis

Identifiers

PMID33096134
PMCPMC8046713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.