ArticleCurrent biology : CB2020
Cortical State Fluctuations during Sensory Decision Making.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 81 citations in OpenAlex.
- The Contribution of the Locus Ceruleus-Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges.Neurobiology of disease · 2025Article
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- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).Neurobiology of disease · 2025Article
- Network influence determines the impact of cortical ensembles on stimulus detection.bioRxiv : the preprint server for biology · 2024Article
- Wide-field imaging in behaving mice as a tool to study cognitive function.Neurophotonics · 2024Review
- WidefieldNeurophotonics · 2024Article
- Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior.Nature communications · 2024Article
- Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8).bioRxiv : the preprint server for biology · 2024Article
- Cortical Networks Relating to Arousal Are Differentially Coupled to Neural Activity and Hemodynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III.Nature communications · 2024Article
- Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice.eLife · 2024Article
- The influence of cortical activity on perception depends on behavioral state and sensory context.Nature communications · 2024Article
- Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice.bioRxiv : the preprint server for biology · 2024Article
- Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior.Nature neuroscience · 2024Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe.Nature communications · 2023Article
- Distinct Features of Interictal Activity Predict Seizure Localization and Burden in a Mouse Model of Childhood Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Why is everyone talking about brain state?Trends in neurosciences · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In many behavioral tasks, cortex enters a desynchronized state where low-frequency fluctuations in population activity are suppressed. The precise behavioral correlates of desynchronization and its global organization are unclear. One hypothesis holds that desynchronization enhances stimulus coding in the relevant sensory cortex. Another hypothesis holds that desynchronization reflects global arousal, such as task engagement. Here, we trained mice on tasks where task engagement could be distinguished from sensory accuracy. Using widefield calcium imaging, we found that performance-related desynchronization was global and correlated better with engagement than with accuracy. Consistent with this link between desynchronization and engagement, rewards had a long-lasting desynchronizing effect. To determine whether engagement-related state changes depended on the relevant sensory modality, we trained mice on visual and auditory tasks and found that in both cases desynchronization was global, including regions such as somatomotor cortex. We conclude that variations in low-frequency fluctuations are predominately global and related to task engagement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.