ArticleCell2020
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4
Abstract read
In one paragraph
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 386 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
386citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
386 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Long COVID among people with HIV: A systematic review and meta-analysis.HIV medicine · 2025Pooled it
- COVID-19 Vaccine Hesitancy Among People Living with HIV: A Systematic Review and Meta-Analysis.AIDS and behavior · 2024Pooled it
- Resolving SARS-CoV-2 CD4Cell reports. Medicine · 2022Pooled it
- Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysis.Molecular medicine (Cambridge, Mass.) · 2022Pooled it
- COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Pooled it
- Allogeneic, off-the-shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high-risk patients.Haematologica · 2023Trial
- Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.Scientific reports · 2022Trial
- Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis.JCI insight · 2022Trial
- SARS-CoV-2-induced IgG repertoires shape T cell responses, microRNA regulation, and autoreactivity according to disease severity.Journal of translational autoimmunity · 2026Article
- Continual integration of single-cell multimodal data with MIRACLE.Nature computational science · 2026Article
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens.Nature immunology · 2026Article
- Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker assay workflows.Cell reports methods · 2026Article
- Protocol for deep phenotyping of human antigen-specific T cells across conventional and unconventional subsets by 22-color spectral flow cytometry.STAR protocols · 2026Article
- Article
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- Prospective Biomarkers of SARS-CoV-2 Vaccine Seroconversion in Patients with Haematological Malignancies.Vaccines · 2026Article
- Peptide-driven identification of TCRs reveals dynamics and phenotypes of CD4 T cells in tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Antigen-specific TScience advances · 2026Article
- Extensive Immunological and Inflammatory Perturbation Underpins the Respiratory Sequelae of Postacute COVID-19.Open forum infectious diseases · 2026Article
326 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Benjamin J MeckiffLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Ciro Ramírez-SuásteguiLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Vicente FajardoLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Serena J CheeFaculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Anthony KusnadiLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Hayley SimonLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Simon EschweilerLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Alba GrifoniLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Emanuela PelosiSouthampton Specialist Virology Center, University Hospitals NHS Foundation Trust, Southampton SO16 6YD, UK.
Daniela WeiskopfLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Alessandro SetteLa Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA.
Ferhat AyLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Grégory SeumoisLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Christian H OttensmeierLa Jolla Institute for Immunology, La Jolla, CA 92037, USA; Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Institute of Translational Medicine, Department of Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool L69 7ZX, UK. Electronic address: cho@soton.ac.uk.
Pandurangan VijayanandLa Jolla Institute for Immunology, La Jolla, CA 92037, USA; Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA. Electronic address: vijay@lji.org.
Funding
Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogensU19AI118626 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2015 to 2026
$36.7MT follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Shane P Crotty · 2019 to 2026
$32.8MEpigenomics of T cells and innate immune cells in human asthmaR01HL114093 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI ARSHAD, SYED HASAN, PETERS, BJOERN · 2011 to 2020
$8.5MStudying the function of human genetic variation in the light of 3D genome organizationR35GM128938 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Ferhat Ay · 2018 to 2026
$4.6MNovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832kFACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514kCancer Research UK 21998NCRR NIH HHS S10 RR027366NHLBI NIH HHS R01 HL114093NIAID NIH HHS U19 AI118626NIAID NIH HHS U19 AI142742NIGMS NIH HHS R35 GM128938NIH HHS S10 OD025052
Abstract
The contribution of CD4
Indexed as
TranscriptomeAdultAgedAged, 80 and overAntibodies, ViralCD4 Lymphocyte CountCohort StudiesCOVID-19EnglandFemaleHumansMaleMiddle AgedReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Severity of Illness IndexAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antigen-reactive T cell enrichmentARTECD4-CTLsCD4(+) T cellsCOVID-19cytotoxichumanSARS-CoV-2scRNA-seqsingle-cell RNA sequencingT(FH)T(REG)
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.